HIV-1 entry into cells requires coordinated changes of the conformation and dynamics of both the fusion protein, gp41, and the lipids in the cell membrane and virus envelope. Commonly proposed features of membrane deformation during fusion include high membrane curvature, lipid disorder, and membrane surface dehydration. The virus envelope and target cell membrane contain a diverse set of phospholipids and cholesterol. To dissect how different lipids interact with gp41 to contribute to membrane...
[NMR paper] Biochemical and NMR characterization of the interactions of Vav2-SH2 domain with lipids and the EphA2 juxtamembrane region on membrane.
Biochemical and NMR characterization of the interactions of Vav2-SH2 domain with lipids and the EphA2 juxtamembrane region on membrane.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--portlandpress.com-images-pubmed-logo.png Related Articles Biochemical and NMR characterization of the interactions of Vav2-SH2 domain with lipids and the EphA2 juxtamembrane region on membrane.
Biochem J. 2020 Sep 08;:
Authors: Ge L, Wu B, Zhang Y, Wang J, Zhao H, Wang J
Abstract
Vav2 is a ubiquitous guanine nucleotide...
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09-13-2020 09:18 AM
[NMR paper] NMR assignment and solution structure of the external DII domain of the yeast Rvb2 protein.
NMR assignment and solution structure of the external DII domain of the yeast Rvb2 protein.
NMR assignment and solution structure of the external DII domain of the yeast Rvb2 protein.
Biomol NMR Assign. 2018 Mar 22;:
Authors: Bragantini B, Rouillon C, Charpentier B, Manival X, Quinternet M
Abstract
We report the nearly complete 1H, 15N and 13C resonance assignment and the solution structure of the external DII domain of the yeast Rvb2 protein, a member of the AAA+ATPase superfamily.
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03-24-2018 12:21 PM
[NMR paper] NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.
NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.
Related Articles NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.
PLoS One. 2016;11(4):e0153501
Authors: Chua GL, Tan SM, Bhattacharjya S
Abstract
Kindlins-1,2 and 3 are FERM domain-containing cytosolic proteins involved in the activation and regulation of integrin-mediated cell adhesion. Apart from binding to integrin ? cytosolic tails, kindlins and the well characterized integrin-activator...
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04-22-2016 08:45 PM
Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding
Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding
Abstract
The envelope glycoprotein gp41 mediates the process of membrane fusion that enables entry of the HIV-1 virus into the host cell. Strong lipid affinity of the ectodomain suggests that its heptad repeat regions play an active role in destabilizing membranes by directly binding to the lipid bilayers and thereby lowering the free-energy barrier for membrane fusion. In such a model, immediately following the shedding of gp120, the N-heptad...
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01-28-2015 05:28 PM
[NMR paper] NMR structures and localization of the potential fusion peptides and the pre-transmembrane region of SARS-CoV: Implications in membrane fusion.
NMR structures and localization of the potential fusion peptides and the pre-transmembrane region of SARS-CoV: Implications in membrane fusion.
NMR structures and localization of the potential fusion peptides and the pre-transmembrane region of SARS-CoV: Implications in membrane fusion.
Biochim Biophys Acta. 2014 Dec 2;
Authors: Mahajan M, Bhattacharjya S
Abstract
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) poses a serious public health hazard. The S2 subunit of the S glycoprotein of SARS-CoV carries out...
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12-06-2014 05:18 PM
[NMR paper] Structural Elucidation of Transmembrane Transporter Protein Bilitranslocase: Conformational analysis of the second transmembrane region TM2 by molecular dynamics and NMR spectroscopy.
Structural Elucidation of Transmembrane Transporter Protein Bilitranslocase: Conformational analysis of the second transmembrane region TM2 by molecular dynamics and NMR spectroscopy.
Related Articles Structural Elucidation of Transmembrane Transporter Protein Bilitranslocase: Conformational analysis of the second transmembrane region TM2 by molecular dynamics and NMR spectroscopy.
Biochim Biophys Acta. 2013 Jun 14;
Authors: Choudhury AR, Perdih A, Zuperl S, Sikorska E, Solmajer T, Jurga S, Zhukov I, Novi? M
Abstract
Membrane proteins...
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Structural Elucidation of Transmembrane Transporter Protein Bilitranslocase: Conformational analysis of the second transmembrane region TM2 by molecular dynamics and NMR spectroscopy
Structural Elucidation of Transmembrane Transporter Protein Bilitranslocase: Conformational analysis of the second transmembrane region TM2 by molecular dynamics and NMR spectroscopy
Publication date: Available online 14 June 2013
Source:Biochimica et Biophysica Acta (BBA) - Biomembranes</br>
Author(s): Amrita Roy Choudhury , Andrej Perdih , Špela Župerl , Emilia Sikorska , Tom Solmajer , Stefan Jurga , Igor Zhukov , Marjana Novi?</br>
Membrane proteins represent about a third of the gene products in most organisms, as revealed by the genome sequencing...
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06-15-2013 08:18 AM
[NMR paper] The interactions of the HIV gp41 fusion peptides with zwitterionic membrane mimics de
The interactions of the HIV gp41 fusion peptides with zwitterionic membrane mimics determined by NMR spectroscopy.
Related Articles The interactions of the HIV gp41 fusion peptides with zwitterionic membrane mimics determined by NMR spectroscopy.
Biochim Biophys Acta. 2004 Nov 17;1667(1):67-81
Authors: Morris KF, Gao X, Wong TC
The wild-type (wt) N-terminal 23-residue fusion peptide (FP) of the human immunodeficiency virus (HIV) fusion protein gp41 and its V2E mutant have been studied by nuclear magnetic resonance (NMR) spectroscopy in...
Interactions of HIV gp41's membrane-proximal external region and transmembrane domain with phospholipid membranes from (31)P NMR
Linear Mode
