Insights into the Structure and Dynamics of Proteins from (19)F Solution NMR Spectroscopy
 

Insights into the Structure and Dynamics of Proteins from (19)F Solution NMR Spectroscopy

^(19)F NMR spectroscopy has recently witnessed a resurgence as an attractive analytical tool for the study of the structure and dynamics of biomolecules in vitro and in cells, despite reports of its applications in biomolecular NMR since the 1970s. The high gyromagnetic ratio, large chemical shift dispersion, and complete absence of the spin 1/2 ^(19)F nucleus from biomolecules results in background-free, high-resolution ^(19)F NMR spectra. The introduction of ^(19)F probes in a few selected...

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