Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy
 

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy

Human heat shock protein 90 (Hsp90) is one of the most important chaperones that play a role in the late stages of protein folding. Errors in the process of the chaperone cycle can lead to diseases such as cancer and neurodegenerative diseases. Therefore, the activity of Hsp90 must be carefully regulated. One of the possibilities is allosteric regulation by its natural allosteric modulators-nucleotides, co-chaperones and client proteins-and synthetic small-molecule allosteric modulators, such as...

More...