[NMR paper] Inhibition of FGFR Signaling by Targeting FGF/FGFR Extracellular Interactions: Towards the Comprehension of the Molecular Mechanism through NMR Approaches
Inhibition of FGFR Signaling by Targeting FGF/FGFR Extracellular Interactions: Towards the Comprehension of the Molecular Mechanism through NMR Approaches
NMR-based approaches play a pivotal role in providing insight into molecular recognition mechanisms, affording the required atomic-level description and enabling the identification of promising inhibitors of protein-protein interactions. The aberrant activation of the fibroblast growth factor 2 (FGF2)/fibroblast growth factor receptor (FGFR) signaling pathway drives several pathologies, including cancer development, metastasis formation, resistance to therapy, angiogenesis-driven pathologies,...
[NMR paper] New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies
New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies
Benzimidazole derivatives are known to be key players in the development of novel anticancer agents. Herein, we aimed to synthesize novel derivatives to target breast cancer. A new series of benzimidazole derivatives conjugated with either six- and five-membered heterocyclic ring or pyrazanobenzimidazoles and pyridobenzimidazole linkers were synthesized yielding compounds 5-8 and 10-14, respectively. Structure elucidation of the newly synthesized compounds was achieved through...
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08-30-2022 08:26 PM
[NMR paper] [Anti-inflammatory mechanism of Crepis crocea based on NF-?B signaling pathway and ~1H-NMR metabonomics].
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Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(4):946-954
Authors: Miao YL, He P, Zhang WX, Zhang WZ, Feng M, Ni Y
Abstract
Based on ~1H-NMR metabonomics technique and Western blot assay, the anti-inflammatory mechanism of Crepis crocea was discussed. In this study, male SD rats were treated with water extract(2.5 g·kg~(-1)) and dexamethasone acetate(6.25×10~(-4) g·kg~(-1)) for one week, and the inflammation model was induced by lipopolysaccharide(LPS). Then the counts of inflammatory cells white blood ceel(WBC),...
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04-03-2020 09:41 PM
[NMR paper] Beyond a fluorescent probe: Inhibition of cell division protein FtsZ by mant-GTP elucidated by NMR and biochemical approaches.
Beyond a fluorescent probe: Inhibition of cell division protein FtsZ by mant-GTP elucidated by NMR and biochemical approaches.
Related Articles Beyond a fluorescent probe: Inhibition of cell division protein FtsZ by mant-GTP elucidated by NMR and biochemical approaches.
ACS Chem Biol. 2015 Aug 6;
Authors: Huecas S, Marcelo F, Perona A, Ruiz LB, Morreale A, Cañada FJ, Jimenez-Barbero J, Andreu JM
Abstract
FtsZ is the organizer of cell division in most bacteria and a target in the quest for new antibiotics. FtsZ is a tubulin-like...
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08-08-2015 12:17 PM
[NMR paper] NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
Related Articles NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
Prog Biophys Mol Biol. 2014 Aug 28;
Authors: Dias DM, Ciulli A
Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information...
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09-02-2014 11:17 PM
[NMR paper] Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy.
Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy.
Related Articles Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy.
Angew Chem Int Ed Engl. 2013 Nov 11;
Authors: Kalbitzer HR, Rosnizeck IC, Munte CE, Narayanan SP, Kropf V, Spoerner M
Abstract
A new type of allosteric inhibition by small molecules is proposed that should be applicable to all proteins involved intrinsically...
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11-13-2013 09:22 PM
[NMR paper] Mechanistic insight into inhibition of two-component system signaling.
Mechanistic insight into inhibition of two-component system signaling.
Related Articles Mechanistic insight into inhibition of two-component system signaling.
Medchemcomm. 2013;4(1):269-277
Authors: Francis S, Wilke KE, Brown DE, Carlson EE
Abstract
Two-component signal transduction systems (TCSs) are commonly used by bacteria to couple environmental stimuli to adaptive responses. Targeting the highly conserved kinase domain in these systems represents a promising strategy for the design of a broad-spectrum antibiotic; however, development...
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02-03-2013 10:19 AM
[NMR paper] Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhib
Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.
Related Articles Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.
Bioorg Med Chem Lett. 2001 Jul 9;11(13):1665-9
Authors: Sundaramoorthi R, Siedem C, Vu CB, Dalgarno DC, Laird EC, Botfield MC, Combs AB, Adams SE, Yuan RW, Weigele M, Narula SS
Detailed analysis of Src SH2 binding by peptides containing a...
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11-19-2010 08:44 PM
[NMR paper] Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studi
Insight into the mechanism of serpin-proteinase inhibition from 2D NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex.
Related Articles Insight into the mechanism of serpin-proteinase inhibition from 2D NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex.
Biochemistry. 2001 May 29;40(21):6284-92
Authors: Peterson FC, Gettins PG
We have used -HSQC NMR to investigate the structural changes that occur in both serpin and proteinase in forming the kinetically trapped...
Inhibition of FGFR Signaling by Targeting FGF/FGFR Extracellular Interactions: Towards the Comprehension of the Molecular Mechanism through NMR Approaches
Linear Mode
