High-resolution (13)C NMR indicates that changes in the dynamics of polyproline II conformations induce collagen I fibrillogenesis
 

High-resolution (13)C NMR indicates that changes in the dynamics of polyproline II conformations induce collagen I fibrillogenesis

Collagen I is a 300 nm long fibrous protein that plays an important role in maintaining the structure of several tissues, such as the dermis, bone, enamel and cornea. In these tissues, collagen is found in the form of fibrils, which can be several microns in length and have different diameters. Collagen-collagen interactions rely mainly on the hydrogen bond (H-bond) network and display a very strong sensitivity to temperature; at the physiological temperature, it forms micro to macro fibrils but...

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