Related ArticlesHeparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective.
Curr Protein Pept Sci. 2014 Aug 25;
Authors: Pomin VH
Abstract
This review paper aims at discussing the major recent achievements in the field of the heparin-binding proteins (HBPs), primarily chemokines and defensins, and their complexes with glycosaminoglycans examined by the solution nuclear magnetic resonance (NMR) spectroscopy. As opposed to the HBPs involved in coagulation (mainly antithrombin and thrombin), and growth factors (especially fibroblast growth factors 1 and 2), which were extensively analyzed in the past, inflammatory chemokines turned out to be the most thoroughly studied HBPs nowadays. Defensins, which structurally and functionally resemble the chemokines, are also under intensive current investigation.
PMID: 25175334 [PubMed - as supplied by publisher]
[NMR paper] NMR Characterization of the electrostatic interaction of the basic residues in HDGF and FGF2 during heparin binding.
NMR Characterization of the electrostatic interaction of the basic residues in HDGF and FGF2 during heparin binding.
Related Articles NMR Characterization of the electrostatic interaction of the basic residues in HDGF and FGF2 during heparin binding.
Biochim Biophys Acta. 2014 Aug 9;
Authors: Chiu LY, Hung KW, Tjong SC, Chiang YW, Sue SC
Abstract
Electrostatic interaction is a major driving force in the binding of proteins to highly acidic glycosaminoglycan, such as heparin. Although NMR backbone chemical shifts have generally...
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08-15-2014 12:53 PM
[NMR paper] NMR approaches for structural analysis of multidomain proteins and complexes in solution.
NMR approaches for structural analysis of multidomain proteins and complexes in solution.
Related Articles NMR approaches for structural analysis of multidomain proteins and complexes in solution.
Prog Nucl Magn Reson Spectrosc. 2014 Jul;80C:26-63
Authors: Göbl C, Madl T, Simon B, Sattler M
Abstract
NMR spectroscopy is a key method for studying the structure and dynamics of (large) multidomain proteins and complexes in solution. It plays a unique role in integrated structural biology approaches as especially information about...
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NMR approaches for structural analysis of multidomain proteins and complexes in solution
NMR approaches for structural analysis of multidomain proteins and complexes in solution
Publication date: Available online 23 May 2014
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): Christoph Göbl , Tobias Madl , Bernd Simon , Michael Sattler</br>
NMR spectroscopy is a key method for studying the structure and dynamics of (large) multidomain proteins and complexes in solution. It plays a unique role in integrated structural biology approaches as especially information about conformational dynamics can be readily obtained at residue...
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05-23-2014 03:21 PM
[NMR paper] Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology.
Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology.
Related Articles Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology.
J Magn Reson. 2014 Apr;241:126-36
Authors: Carlomagno T
Abstract
Nucleic acids are gaining enormous importance as key molecules in almost all biological processes. Most nucleic acids do not act in isolation but are generally associated with proteins to form high-molecular-weight nucleoprotein complexes. In this perspective...
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03-25-2014 11:49 AM
Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology
Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology
Publication date: April 2014
Source:Journal of Magnetic Resonance, Volume 241</br>
Author(s): Teresa Carlomagno</br>
Nucleic acids are gaining enormous importance as key molecules in almost all biological processes. Most nucleic acids do not act in isolation but are generally associated with proteins to form high-molecular-weight nucleoprotein complexes. In this perspective article I focus on the structural studies of supra-molecular ribonucleoprotein (RNP) assemblies...
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03-21-2014 12:52 AM
[NMR paper] Solution NMR conformation of glycosaminoglycans.
Solution NMR conformation of glycosaminoglycans.
Related Articles Solution NMR conformation of glycosaminoglycans.
Prog Biophys Mol Biol. 2014 Feb 19;
Authors: Pomin VH
Abstract
Nuclear magnetic resonance (NMR) spectroscopy has been giving a pivotal contribution to the progress of glycomics, mostly by elucidating the structural, dynamical, conformational and intermolecular binding aspects of carbohydrates. Particularly in the field of conformation, NOE resonances, scalar couplings, residual dipolar couplings, and chemical shift...
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[NMR paper] Investigation of Lysine Side Chain Interactions of Interleukin-8 with Heparin and other Glycosaminoglycans Studied by a Methylation-NMR Approach.
Investigation of Lysine Side Chain Interactions of Interleukin-8 with Heparin and other Glycosaminoglycans Studied by a Methylation-NMR Approach.
Investigation of Lysine Side Chain Interactions of Interleukin-8 with Heparin and other Glycosaminoglycans Studied by a Methylation-NMR Approach.
Glycobiology. 2013 Aug 27;
Authors: Möbius K, Nordsieck K, Pichert A, Samsonov SA, Thomas L, Schiller J, Kalkhof S, Pisabarro MT, Beck-Sickinger AG, Huster D
Abstract
Although the interaction between interleukin-8 (IL-8) and glycosaminoglycans (GAG) is...
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[NMR paper] Heparin binding to platelet factor-4. An NMR and site-directed mutagenesis study: arg
Heparin binding to platelet factor-4. An NMR and site-directed mutagenesis study: arginine residues are crucial for binding.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Heparin binding to platelet factor-4. An NMR and site-directed mutagenesis study: arginine residues are crucial for binding.
Biochem J. 1995 Dec 1;312 ( Pt 2):357-65
Authors: Mayo KH, Ilyina E, Roongta V, Dundas M, Joseph J, Lai CK, Maione T, Daly TJ
Native platelet factor-4 (PF4) is an...
Heparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective.
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