A Fusion Protein of the p53 Transaction Domain andthe p53-Binding Domain of the Oncoprotein MdmX as an Efficient Systemfor High-Throughput Screening of MdmX Inhibitors
A Fusion Protein of the p53 Transaction Domain andthe p53-Binding Domain of the Oncoprotein MdmX as an Efficient Systemfor High-Throughput Screening of MdmX Inhibitors
[NMR paper] High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
ChemMedChem. 2015 Nov 23;
Authors: Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
Abstract
Recently we described a novel approach, named high-throughput screening (HTS) by NMR that allows the identification, from large combinatorial peptide libraries, of potent and selective...
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11-26-2015 12:13 AM
[NMR paper] High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists.
High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists.
High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists.
Curr Top Med Chem. 2015 May 18;
Authors: Wu B, Barile E, De SK, Wei J, Purves A, Pellecchia M
Abstract
In recent years the ever so complex field of drug discovery has embraced novel design strategies based on biophysical fragment screening (fragment-based drug design; FBDD) using nuclear magnetic resonance...
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05-20-2015 10:27 AM
High-Throughput Protein Interaction and Stability Screening - Genetic Engineering & Biotechnology News
High-Throughput Protein Interaction and Stability Screening - Genetic Engineering & Biotechnology News
http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcRO2AuWghPYta2wz5uoh-agqOm8dSB5EKAHvV7KWsTMoDkCHeVnTsPlMYAQV7CIi5igLEPP8IE
Genetic Engineering & Biotechnology News
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High-Throughput Protein Interaction and Stability Screening
Genetic Engineering & Biotechnology News
Historically, protein interaction and stability have been measured using a variety of techniques, including nuclear magnetic resonance (NMR), differential scanning calorimetry...
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05-15-2015 07:52 AM
[NMR paper] Detergent/Nanodisc screening for high-resolution NMR studies of an integral membrane protein containing a cytoplasmic domain.
Detergent/Nanodisc screening for high-resolution NMR studies of an integral membrane protein containing a cytoplasmic domain.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Detergent/Nanodisc screening for high-resolution NMR studies of an integral membrane protein containing a cytoplasmic domain.
PLoS One. 2013;8(1):e54378
Authors: Tzitzilonis C, Eichmann C, Maslennikov I, Choe...
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02-03-2013 10:19 AM
[NMR paper] High-throughput screening of structural proteomics targets using NMR.
High-throughput screening of structural proteomics targets using NMR.
Related Articles High-throughput screening of structural proteomics targets using NMR.
FEBS Lett. 2003 Sep 25;552(2-3):207-13
Authors: Galvão-Botton LM, Katsuyama AM, Guzzo CR, Almeida FC, Farah CS, Valente AP
We applied a high-throughput strategy for the screening of targets for structural proteomics of Xanthomonas axonopodis pv citri. This strategy is based on the rapid (1)H-(15)N HSQC NMR analysis of bacterial lysates containing selectively (15)N-labelled heterologous...
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11-24-2010 09:16 PM
[NMR paper] Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practica
Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations, and range of applicability.
Related Articles Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations, and range of applicability.
J Am Chem Soc. 2003 Jun 25;125(25):7696-703
Authors: Dalvit C, Fagerness PE, Hadden DT, Sarver RW, Stockman BJ
Competition ligand-based NMR screening experiments have recently been introduced to overcome most of the problems associated with traditional ligand-based NMR...
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11-24-2010 09:01 PM
[NMR paper] Integration of NMR and high-throughput screening.
Integration of NMR and high-throughput screening.
Related Articles Integration of NMR and high-throughput screening.
Comb Chem High Throughput Screen. 2002 Dec;5(8):613-21
Authors: Hajduk PJ, Burns DJ
NMR-based screening has become a powerful method for the identification and analysis of low-molecular weight organic compounds that bind to protein targets and can be utilized in drug discovery programs. In particular, heteronuclear NMR-based screening can yield information about both the affinity and binding location of potential lead compounds....
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11-24-2010 08:58 PM
[NMR paper] An efficient high-throughput resonance assignment procedure for structural genomics a
An efficient high-throughput resonance assignment procedure for structural genomics and protein folding research by NMR.
Related Articles An efficient high-throughput resonance assignment procedure for structural genomics and protein folding research by NMR.
Biochemistry. 2001 Dec 11;40(49):14727-35
Authors: Bhavesh NS, Panchal SC, Hosur RV
Sequence specific resonance assignment is the primary requirement for all investigations of proteins by NMR methods. In the present postgenomic era where structural genomics and protein folding have...
A Fusion Protein of the p53 Transaction Domain andthe p53-Binding Domain of the Oncoprotein MdmX as an Efficient Systemfor High-Throughput Screening of MdmX Inhibitors
Linear Mode
