The eukaryotic genome is packaged into chromatin, a polymer of DNA and histone proteins that regulates gene expression and the spatial organization of nuclear content. The repetitive character of chromatin is diversified into rich layers of complexity that encompass DNA sequence, histone variants and post-translational modifications. Subtle molecular changes in these variables can often lead to global chromatin rearrangements that dictate entire gene programs with far reaching implications for...
[NMR paper] New applications of solid-state NMR in structural biology.
New applications of solid-state NMR in structural biology.
Related Articles New applications of solid-state NMR in structural biology.
Emerg Top Life Sci. 2018 Apr 20;2(1):57-67
Authors: van der Wel PCA
Abstract
Various recent developments in solid-state nuclear magnetic resonance (ssNMR) spectroscopy have enabled an array of new insights regarding the structure, dynamics, and interactions of biomolecules. In the ever more integrated world of structural biology, ssNMR studies provide structural and dynamic information that is...
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06-19-2018 08:46 PM
Unique Insights into the Structural and Functional Biology of Membrane Proteins from Solid State NMR Spectroscopy
Unique Insights into the Structural and Functional Biology of Membrane Proteins from Solid State NMR Spectroscopy
Publication date: 2 February 2018
Source:Biophysical Journal, Volume 114, Issue 3, Supplement 1</br>
Author(s): Timothy Cross, Joana Paulino, Huajun Qin, Yiseul Shin, Cristian Escobar, Rongfu Zhang, Joshua Taylor, Yimin Miao, Riqiang Fu, Eduard Chekmenev, Ivan Hung, Zhehong Gan, Petr Gor'kov</br>
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02-07-2018 03:41 PM
[NMR paper] Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR.
Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-cellhub.gif Related Articles Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR.
Trends Biochem Sci. 2017 Oct;42(10):777-787
Authors: Meier BH, Riek R, Böckmann A
Abstract
Amyloid structures at atomic resolution have remained elusive mainly because of their extensive polymorphism and because their polymeric properties have hampered...
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10-12-2017 02:58 PM
[NMR] Postdoctoral position in chromatin structural biology at UC, San Diego
From The DNP-NMR Blog:
Postdoctoral position in chromatin structural biology at UC, San Diego
The Debelouchina lab at the University of California, San Diego is looking for a motivated postdoctoral researcher to join our growing team. Our work combines NMR spectroscopy tools with chemical and cell biology techniques to study chromatin and gene regulation. This position will provide the candidate with the opportunity to apply and/or learn solid-state and solution NMR methods, protein and peptide synthesis, protein biochemistry, as well as cell biology techniques. Candidates must hold a...
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09-06-2017 02:35 AM
[NMR paper] Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.
Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.
Related Articles Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.
J Phys Chem B. 2017 Apr 20;:
Authors: Qin H, Miao Y, Cross TA, Fu R
Abstract
In terms of structural biology, solid-state NMR experiments and strategies have been well established for resonance assignments leading to the...
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04-21-2017 03:35 PM
Structural biology applications of solid state MAS DNP NMR #DNPNMR
From The DNP-NMR Blog:
Structural biology applications of solid state MAS DNP NMR #DNPNMR
Akbey, U. and H. Oschkinat, Structural biology applications of solid state MAS DNP NMR. J Magn Reson, 2016. 269: p. 213-24.
http://www.ncbi.nlm.nih.gov/pubmed/27095695
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08-31-2016 02:34 PM
[NMR paper] Solid-state NMR: An emerging technique in structural biology of self-assemblies.
Solid-state NMR: An emerging technique in structural biology of self-assemblies.
Related Articles Solid-state NMR: An emerging technique in structural biology of self-assemblies.
Biophys Chem. 2015 Jul 16;
Authors: Habenstein B, Loquet A
Abstract
Protein self-assemblies are ubiquitous biological systems involved in many cellular processes, ranging from bacterial and viral infection to the propagation of neurodegenerative disorders. Studying the atomic three-dimensional structures of protein self-assemblies is a particularly...
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08-04-2015 03:00 PM
Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology
From The DNP-NMR Blog:
Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology
Gelis, I., et al., Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology. J. Biomol. NMR, 2013. 56(2): p. 85-93.
http://dx.doi.org/10.1007/s10858-013-9721-2
Emerging Contributions of Solid-State NMR Spectroscopy to Chromatin Structural Biology
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