Early events in amyloid-? self-assembly probed by time-resolved solid state NMR and light scattering
 

Early events in amyloid-? self-assembly probed by time-resolved solid state NMR and light scattering

Self-assembly of amyloid-? peptides leads to oligomers, protofibrils, and fibrils that are likely instigators of neurodegeneration in Alzheimer's disease. We report results of time-resolved solid state nuclear magnetic resonance (ssNMR) and light scattering experiments on 40-residue amyloid-? (A?40) that provide structural information for oligomers that form on time scales from 0.7 ms to 1.0 h after initiation of self-assembly by a rapid pH drop. Low-temperature ssNMR spectra of freeze-trapped...

More...