A Dynamic Look Backward and Forward
 

A Dynamic Look Backward and Forward

Publication date: Available online 11 February 2016
Source:Journal of Magnetic Resonance</br>
Author(s): Arthur G. Palmer</br>
The 2015 Gunther Laukien Prize recognized solution NMR studies of protein dynamics and thermodynamics. This Perspective surveys aspects of the development and application of NMR spin relaxation for investigations of protein flexibility and function over multiple time scales in solution. Methods highlighted include analysis of overall rotational diffusion, theoretical descriptions of R 1 ? relaxation, and molecular dynamics simulations to interpret NMR spin relaxation. Applications are illustrated for the zinc-finger domain Xfin-31, the calcium-binding proteins calbindin D9k and calmodulin, and the bZip transcription factor of GCN4.
Graphical abstract

http://origin-ars.els-cdn.com/conten...000604-fx1.jpg</br></br>
</br></br>

More...