DAXX protein, also known as a "death-associated factor", is an important player in many cell cycle processes. However the detailed molecular structure of this important protein has not been reported. In this cover article in StructureLawrence McIntosh (UBC) and his team has discovered using NMR spectroscopy that the C-terminal half of DAXX is intrinsically disordered, whereas the N-terminal portion contains a well-folded helical bundle domain. This important work provides a structural foundation for understanding the diverse functions of DAXX.
E. Escobar-Cabrera, D.K.W. Lau, S. Giovinazzi, A.M. Ishov, L.P. McIntosh, "Structural Characterization of the DAXX N-Terminal Helical Bundle Domain and Its Complex with Rassf1C," Structure 18 (2010) 1642–1653. (Cover Article)http://dx.doi.org/10.1016/j.str.2010.09.016
[NMR900 blog] Cover article in Organic & Biomolecular Chemistry
Cover article in Organic & Biomolecular Chemistry
J. Guimond-Tremblay, M.-C. Gagnon, J.-A. Pineault-Maltais, V. Turcotte, M. Auger, J.-F. Paquin, "Synthesis and properties of monofluorinated dimyristoylphosphatidylcholine derivatives: Potential fluorinated probes for the study of membrane topology," Organic and Biomolecular Chemistry 10 (2012) 1145-1148. (Cover Article) http://dx.doi.org/10.1039/c2ob06570c https://blogger.googleusercontent.com/tracker/8663203727601106205-5483999220580812850?l=nmr900.blogspot.com
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02-24-2012 10:27 AM
[NMR900 blog] Cover article in the Journal of the American Chemical Society
Cover article in the Journal of the American Chemical Society
Gang Wu, Zhehong Gan, Irene C. M. Kwan, James C. Fettinger, and Jeffery T. Davis, "High Resolution 39K NMR Spectroscopy of Bio-organic Solids," J. Am. Chem. Soc. 133 (2011) 19570–19573. (cover article) http://dx.doi.org/10.1021/ja2052446https://blogger.googleusercontent.com/tracker/8663203727601106205-6955654220933917402?l=nmr900.blogspot.com
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12-08-2011 10:27 AM
[NMR900 blog] Cover article in Physical Chemistry Chemical Physics
Cover article in Physical Chemistry Chemical Physics
Cory M. Widdifield, Alex D. Bain, and David L. Bryce, "Definitive Solid-State 185/187Re NMR Spectral Evidence for and Analysis of the Origin of High-Order Quadrupole-Induced Effects for I = 5/2," Physical Chemistry Chemical Physics 13 (2011) 12413-12420. (Cover Article) http://dx.doi.org/10.1039/c1cp20572b
This is the tenth cover article featuring results obtained using resources of the National Ultrahigh-Field NMR Facility for Solids. See our cover gallery and the complete list of research publications enabled by the Facility here...
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07-05-2011 05:52 AM
[NMR900 blog] Cover article in Chemistry - A European Journal
Cover article in Chemistry - A European Journal
H.N. Hunter, N. Hadei, V. Blagojevic, P. Patschinski, G.T. Achonduh, S. Avola, D.K. Bohme, M.G. Organ, "Identification of a Higher-Order Organozincate Intermediate Involved in Negishi Cross-Coupling Reactions by Mass Spectrometry and NMR Spectroscopy," Chemistry - A European Journal 17 (2011) 7845–7851. (Cover article) http://dx.doi.org/10.1002/chem.201190141https://blogger.googleusercontent.com/tracker/8663203727601106205-8010804243019211566?l=nmr900.blogspot.com
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06-23-2011 03:53 AM
[NMR900 blog] Cover article in Chemistry - A European Journal
Cover article in Chemistry - A European Journal
B.J. Greer, V.K. Michaelis, M.J. Katz, D.B. Leznoff, G. Schreckenbach, S. Kroeker, "Characterising Lone-Pair Activity of Lead(II) by 207Pb Solid-State NMR: Coordination Polymers of - and - with Terpyridine Ancillary Ligands," Chemistry - A European Journal 17 (2011) 3609-3618. http://dx.doi.org/10.1002/chem.201002913 https://blogger.googleusercontent.com/tracker/8663203727601106205-6619588252539620091?l=nmr900.blogspot.com
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03-13-2011 05:24 AM
[NMR900 blog] Cover article in Angewandte Chemie
Cover article in Angewandte Chemie
Low concentration and poor sensitivity often hinder or make impossible solid-state 17O NMR in large biomolecular systems. In this cover article in Angewandte Chemie Gang Wu (Queen’s) and co-workers from the University of Ottawa and NRC Canada show that at an ultrahigh magnetic field of 21 T the high quality solid-state 17O NMR spectra can be obtained for large protein–ligand complexes of up to 300 kDa in size. Complementary multinuclear 17O, 27Al, and 13C NMR data obtained in this work have aided in the structural refinement for an ovotransferrin bound...
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11-01-2010 11:07 PM
[NMR900 blog] Cover article in Dalton Transactions
Cover article in Dalton Transactions
David Bryce (University of Ottawa) has written a Perspective for Dalton Transactions about recent advancements in 43Ca NMR spectroscopy and its applications in materials science.
David L. Bryce "Calcium Binding Environments Probed by 43Ca NMR Spectroscopy," Dalton Transactions 39 (2010) 8593-8602. (Cover Article). http://dx.doi.org/10.1039/c0dt00416b
This Perspective is featured on the cover of the current Dalton Transaction issue (2010, #37), and was recently highlighted by SpectroscopyNow.
This is an eighth cover article featuring results...
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09-15-2010 04:10 PM
[Ryan's blog] Is There Hope for Fully Automated Structure Elucidation?- New Article Published
Source: Ryan's blog
Is There Hope for Fully Automated Structure Elucidation?- New Article Published
Computer Assisted Structure Elucidation (CASE) is a major challenge in and of itself. We've been working on this for many, many years and we continue to make huge strides in this area. The technology is sound, the software is being...