[NMR paper] High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
ChemMedChem. 2015 Nov 23;
Authors: Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
Abstract
Recently we described a novel approach, named high-throughput screening (HTS) by NMR that allows the identification, from large combinatorial peptide libraries, of potent and selective...
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11-26-2015 12:13 AM
[NMR paper] Further exploration of the conformational space of ?-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.
Further exploration of the conformational space of ?-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.
Related Articles Further exploration of the conformational space of ?-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph.
Biomol NMR Assign. 2015 Aug 30;
Authors: Verasdonck J, Bousset L, Gath J, Melki R, Böckmann A, Meier BH
Abstract
Polymorphism is a common and important phenomenon for protein fibrils which has been linked to the appearance of strains in prion and other neurodegenerative...
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09-01-2015 10:48 AM
[NMR paper] High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists.
High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists.
High-throughput screening by Nuclear Magnetic Resonance (HTS by NMR) for the identification of PPIs antagonists.
Curr Top Med Chem. 2015 May 18;
Authors: Wu B, Barile E, De SK, Wei J, Purves A, Pellecchia M
Abstract
In recent years the ever so complex field of drug discovery has embraced novel design strategies based on biophysical fragment screening (fragment-based drug design; FBDD) using nuclear magnetic resonance...
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05-20-2015 10:27 AM
High-Throughput Protein Interaction and Stability Screening - Genetic Engineering & Biotechnology News
High-Throughput Protein Interaction and Stability Screening - Genetic Engineering & Biotechnology News
http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcRO2AuWghPYta2wz5uoh-agqOm8dSB5EKAHvV7KWsTMoDkCHeVnTsPlMYAQV7CIi5igLEPP8IE
Genetic Engineering & Biotechnology News
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High-Throughput Protein Interaction and Stability Screening
Genetic Engineering & Biotechnology News
Historically, protein interaction and stability have been measured using a variety of techniques, including nuclear magnetic resonance (NMR), differential scanning calorimetry...
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05-15-2015 07:52 AM
[NMR paper] High-throughput screening of structural proteomics targets using NMR.
High-throughput screening of structural proteomics targets using NMR.
Related Articles High-throughput screening of structural proteomics targets using NMR.
FEBS Lett. 2003 Sep 25;552(2-3):207-13
Authors: Galvão-Botton LM, Katsuyama AM, Guzzo CR, Almeida FC, Farah CS, Valente AP
We applied a high-throughput strategy for the screening of targets for structural proteomics of Xanthomonas axonopodis pv citri. This strategy is based on the rapid (1)H-(15)N HSQC NMR analysis of bacterial lysates containing selectively (15)N-labelled heterologous...
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11-24-2010 09:16 PM
[NMR paper] Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practica
Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations, and range of applicability.
Related Articles Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations, and range of applicability.
J Am Chem Soc. 2003 Jun 25;125(25):7696-703
Authors: Dalvit C, Fagerness PE, Hadden DT, Sarver RW, Stockman BJ
Competition ligand-based NMR screening experiments have recently been introduced to overcome most of the problems associated with traditional ligand-based NMR...
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11-24-2010 09:01 PM
[NMR paper] Integration of NMR and high-throughput screening.
Integration of NMR and high-throughput screening.
Related Articles Integration of NMR and high-throughput screening.
Comb Chem High Throughput Screen. 2002 Dec;5(8):613-21
Authors: Hajduk PJ, Burns DJ
NMR-based screening has become a powerful method for the identification and analysis of low-molecular weight organic compounds that bind to protein targets and can be utilized in drug discovery programs. In particular, heteronuclear NMR-based screening can yield information about both the affinity and binding location of potential lead compounds....
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11-24-2010 08:58 PM
Broadband 15Nâ??13C dipolar recoupling via symmetry-based RF pulse schemes at high MA
Abstract An approach for generating efficient
RNnnS, nk symmetry-based dual channel RF pulse schemes for γ-encoded broadband 15Nâ??13C dipolar recoupling at high magic angle spinning frequencies is presented. The method involves the numerical optimisation of the RF phase-modulation profile of the basic â??Râ?? element so as to obtain heteronuclear double quantum dipolar recoupling sequences with satisfactory magnetisation transfer characteristics. The basic â??Râ?? element was implemented as a sandwich of a small number of short pulses of equal duration with each pulse characterised by...
Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband 19F NMR-Based Screening
Linear Mode
