Invasive aspergillosis poses a significant threat to immunocompromised patients, leading to high mortality rates associated with these infections. Targeting the biosynthesis of cell wall carbohydrates is a promising strategy for antifungal drug development and will be advanced by a molecular-level understanding of the native structures of polysaccharides within their cellular context. Solid-state NMR spectroscopy has recently provided detailed insights into the cell wall organization of...
[NMR paper] New Vision of Cell Walls in Aspergillus fumigatus from Solid-State NMR Spectroscopy
New Vision of Cell Walls in Aspergillus fumigatus from Solid-State NMR Spectroscopy
The fungal cell wall plays a critical role in regulating cellular integrity and communication, and serves as a frontline defense against stress. It is also a prime target for the development of antifungal agents. The cell wall is comprised of diverse polysaccharides and proteins and poses a challenging target for high-resolution structural characterization. Recently, the solid-state nuclear magnetic resonance (ssNMR) analysis of intact Aspergillus fumigatus cells has provided atomic-level...
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03-27-2024 07:01 PM
Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition
Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition
Gaëlle LamonAlons LendsIsabel ValsecchiSarah Sze Wah WongVincent DuprèsFrank LafontJames TolchardChristine SchmittAdeline MalletAxelle GrélardEstelle MorvanErick J. DufourcBirgit HabensteinJ. Iñaki GuijarroVishukumar AimaniandaAntoine LoquetaUniv. Bordeaux, Centre National de la Recherche Scientifique (CNRS), Bordeaux Institut National Polytechnique, Chemistry and Biology of Membranes and Nanoobjects (CBMN), Unité Mixte de Recherche (UMR) 5248, Institut Européen de...
[NMR paper] Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus.
Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus.
Related Articles Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus.
Front Microbiol. 2016;7:1794
Authors: Han X, Qiu M, Wang B, Yin WB, Nie X, Qin Q, Ren S, Yang K, Zhang F, Zhuang Z, Wang S
Abstract
In Aspergillus nidulans, the nitrogen metabolite repression (NMR) regulator NmrA plays a major role in regulating the activity of the GATA transcription factor AreA during nitrogen...
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12-11-2016 06:23 AM
Water–Polysaccharide Interactions in the Primary Cell Wall of Arabidopsis thaliana from Polarization Transfer Solid-State NMR
Water–Polysaccharide Interactions in the Primary Cell Wall of Arabidopsis thaliana from Polarization Transfer Solid-State NMR
Paul B. White, Tuo Wang, Yong Bum Park, Daniel J. Cosgrove and Mei Hong
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja504108h/aop/images/medium/ja-2014-04108h_0009.gif
Journal of the American Chemical Society
DOI: 10.1021/ja504108h
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/7abtnNxi-xg
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07-15-2014 09:25 AM
[NMR paper] The Aspergillus nidulans transcription factor AlcR forms a stable complex with its ha
The Aspergillus nidulans transcription factor AlcR forms a stable complex with its half-site DNA: a NMR study.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles The Aspergillus nidulans transcription factor AlcR forms a stable complex with its half-site DNA: a NMR study.
FEBS Lett. 1997 May 19;408(2):235-40
Authors: Cerdan R, Collin D, Lenouvel F, Felenbok B, Guittet E
The Aspergillus nidulans transcription factor AlcR is shown by NMR and gel retardation assay to form a...
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08-22-2010 03:31 PM
[NMR paper] The Aspergillus nidulans transcription factor AlcR forms a stable complex with its ha
The Aspergillus nidulans transcription factor AlcR forms a stable complex with its half-site DNA: a NMR study.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles The Aspergillus nidulans transcription factor AlcR forms a stable complex with its half-site DNA: a NMR study.
FEBS Lett. 1997 May 19;408(2):235-40
Authors: Cerdan R, Collin D, Lenouvel F, Felenbok B, Guittet E
The Aspergillus nidulans transcription factor AlcR is shown by NMR and gel retardation assay to form a...
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08-22-2010 03:03 PM
[NMR paper] NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence
NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism.
Related Articles NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism.
Biochemistry. 1995 Mar 7;34(9):3009-21
Authors: Campos-Olivas R, Bruix M, Santoro J, Lacadena J, Martinez del Pozo A, Gavilanes JG, Rico M
The solution structure of the antifungal protein (AFP, 51 residues, 4 disulfide bridges) from Aspergillus giganteus has been determined by using...