?,?-CHF- and?,?-CHCl-dGTPDiastereomers: Synthesis, Discrete 31P*NMR Signatures,and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
?,?-CHF- and?,?-CHCl-dGTPDiastereomers: Synthesis, Discrete 31P*NMR Signatures,and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
Metabolic signatures of cancer unveiled by NMR spectroscopy of human biofluids
Metabolic signatures of cancer unveiled by NMR spectroscopy of human biofluids
Publication year: 2011
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, Available online 29 November 2011</br>
Iola F.*Duarte, Ana M.*Gil</br>
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12-01-2011 12:33 PM
[NMR paper] Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand inter
Synthesis of -enriched bile salts as NMR probes of protein-ligand interactions.
Related Articles Synthesis of -enriched bile salts as NMR probes of protein-ligand interactions.
J Org Chem. 2002 Sep 20;67(19):6764-71
Authors: Tochtrop GP, DeKoster GT, Cistola DP, Covey DF
Synthetic methodology that allows for incorporation of isotopic carbon at the C-3 and C-4 positions of bile salts is reported. Three -enriched bile salts were synthesized from either deoxycholic or lithocholic acid. The steroid 3alpha-OH group was oxidized and the A-ring was...
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11-24-2010 08:58 PM
[NMR paper] A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of
A simple efficient synthesis of -(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions.
Related Articles A simple efficient synthesis of -(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions.
Bioorg Med Chem Lett. 2002 Feb 11;12(3):433-5
Authors: Tochtrop GP, DeKoster GT, Cistola DP, Covey DF
The synthesis of -(13)C(2)-labeled bile salts is achieved through a steroidal side chain degradation and isotopic regeneration strategy. Three common bile acids were degraded to the corresponding C(22 )aldehyde by an...
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11-24-2010 08:49 PM
[NMR paper] The (17)O-NMR shielding range and shielding time scale and detection of discrete hydr
The (17)O-NMR shielding range and shielding time scale and detection of discrete hydrogen-bonded conformational states in peptides.
Related Articles The (17)O-NMR shielding range and shielding time scale and detection of discrete hydrogen-bonded conformational states in peptides.
Biopolymers. 2001 Sep;59(3):125-30
Authors: Gerothanassis IP
The (17)O-NMR shielding range and shielding time scale due to hydrogen-bonding interactions in peptides are critically evaluated relative to those of (1)H-NMR. Furthermore, the assumptions and conclusions in...
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11-19-2010 08:44 PM
[NMR paper] NMR strategy for determining Xaa-Pro peptide bond configurations in proteins: mutants
NMR strategy for determining Xaa-Pro peptide bond configurations in proteins: mutants of staphylococcal nuclease with altered configuration at proline-117.
Related Articles NMR strategy for determining Xaa-Pro peptide bond configurations in proteins: mutants of staphylococcal nuclease with altered configuration at proline-117.
Biochemistry. 1993 Nov 9;32(44):11810-8
Authors: Hinck AP, Eberhardt ES, Markley JL
A general approach has been developed for configurational analysis (cis or trans) of Xaa-Pro peptide bonds in proteins. This approach,...
Iterative algorithm of discrete Fourier transform for processing randomly sampled NMR
Abstract Spectra obtained by application of multidimensional Fourier Transformation (MFT) to sparsely sampled nD NMR signals are usually corrupted due to missing data. In the present paper this phenomenon is investigated on simulations and experiments. An effective iterative algorithm for artifact suppression for sparse on-grid NMR data sets is discussed in detail. It includes automated peak recognition based on statistical methods. The results enable one to study NMR spectra of high dynamic range of peak intensities preserving benefits of random sampling, namely the superior resolution in...