Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from ... - Nature.com
Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from ... - Nature.com
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Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from ...
Nature.com
The 1H and 13C NMR spectra (in acetone-d6) showed 23 proton and 16 carbon signals (Table 1) that were classified into one methyl, eight sp3 methylene, two sp3 oxygenated methine, two sp2 methine, two sp2 quaternary and one carbonyl carbons through ...
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04-22-2015 03:33 PM
Insecticidal fungi: Enzyme inhibitors extracted
Insecticidal fungi: Enzyme inhibitors extracted
http://www.spectroscopynow.com/common/images/thumbnails/149a327c9ae.jpgScreening of dozens of strains of fungi that infect insects has led to the discovery of a strong inhibitor for the enzyme tyrosinase. Tyrosinase activity is involved in insect development processes but also in human aging, the development of melanoma, wound healing, and even in the browning of fruits and vegetables.
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11-15-2014 01:47 PM
[NMR paper] A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles A Chemical-biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) inhibitors.
J Med Chem. 2013 Jan 30;
Authors: Dal Piaz F, Vassallo A, Temraz A, Cotugno R, Belisario MA, Bifulco G, Chini MG, Pisano C, De Tommasi N, Braca A
Abstract
The potential of Heat Shock Protein 90 (Hsp90) as a therapeutic target...
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02-03-2013 10:19 AM
[NMR paper] The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors
The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors.
Related Articles The application of x-ray, NMR, and molecular modeling in the design of MMP inhibitors.
Curr Top Med Chem. 2004;4(12):1311-27
Authors: Rush TS, Powers R
The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFalpha-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts...
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11-24-2010 09:25 PM
[NMR paper] 1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A a
1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.
Related Articles 1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.
Bioorg Med Chem Lett. 2004 Mar 22;14(6):1585-8
Authors: Li Y, Li Q, Sun M, Song G, Jiang S, Zhu D
The binding properties of huperzine A (1) with Torpediniforms Nacline acetylcholinesterase (TnAChE) were investigated by (1)H NMR methods. The noselective, selective and double-selective spin-lattice relaxation rates were acquired in...
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11-24-2010 09:25 PM
[NMR paper] In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5
In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.
Related Articles In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.
J Med Chem. 2002 Dec 19;45(26):5655-60
Authors: Kamionka M, Rehm T, Beisel HG, Lang K, Engh RA, Holak TA
Recently we have determined the crystal structure of the insulin-like growth factor-I (IGF-I) in complex with the N-terminal domain of the IGF-binding protein-5 (IGFBP-5). Here we report results of computer screening for...
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11-24-2010 08:58 PM
[NMR paper] Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
Related Articles Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
J Med Chem. 1999 Sep 23;42(19):3852-9
Authors: Hajduk PJ, Dinges J, Schkeryantz JM, Janowick D, Kaminski M, Tufano M, Augeri DJ, Petros A, Nienaber V, Zhong P, Hammond R, Coen M, Beutel B, Katz L, Fesik SW
The Erm family of methyltransferases confers resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics through the methylation of 23S ribosomal RNA. Upon...
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11-18-2010 08:31 PM
[NMR paper] Structural characterization of the interactions of optimized product inhibitors with
Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.
J Mol Biol. 1999 Jun 4;289(2):385-96
Authors: Cicero...
Chemical Inhibitors of Epigenetic Methyllysine ReaderProteins
Linear Mode
