MRI of chemical reactions and processes
MRI of chemical reactions and processes
Publication date: Available online 30 March 2017
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): Melanie M. Britton</br>
As magnetic resonance imaging (MRI) can spatially resolve a wealth of molecular information available from nuclear magnetic resonance (NMR), it is able to non-invasively visualise the composition, properties and reactions of a broad range of spatially-heterogeneous molecular systems. Hence, MRI is increasingly finding applications in the study of chemical reactions and processes...
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Journal club
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04-01-2017 02:53 AM
[NMR paper] Protein-templated fragment ligations - from molecular recognition to drug discovery
Protein-templated fragment ligations - from molecular recognition to drug discovery
The understanding and manipulation of molecular recognition events is the key to modern approaches in drug discovery. Protein-templated fragment ligation is a novel concept to support drug discovery and can help to improve the efficacy of already existing protein ligands. Protein-templated fragment ligations are chemical reactions between small molecules ("fragments") that utilize a protein´s surface as a template to combine and to form a protein ligand with increased binding affinity. The...
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Journal club
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01-24-2017 08:12 PM
Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions #DNPNMR
From The DNP-NMR Blog:
Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions #DNPNMR
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Lee, Y., Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions. Applied Spectroscopy Reviews, 2015. 51(3): p. 210-226.
https://doi.org/10.1080/05704928.2015.1116078
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News from NMR blogs
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12-30-2016 04:53 PM
[NMR paper] Weak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.
Weak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.
Related Articles Weak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.
Chemistry. 2016 Apr 26;
Authors: Dalvit C, Vulpetti A
Abstract
It is known that strong hydrogen-bonding interactions play an important role in many chemical and...
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Journal club
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04-27-2016 01:51 PM
Saucy solution: HIV antivirals
Saucy solution: HIV antivirals
http://www.spectroscopynow.com/common/images/thumbnails/145efd6e885.jpgUS researchers are using nuclear magnetic resonance spectroscopy to help inform their virology efforts in the hope of develop new, potent antiviral agents for the treatment of HIV, human immunodeficiency virus.
Read the rest at Spectroscopynow.com
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General
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05-15-2014 06:14 AM
[Question from NMRWiki Q&A forum] Chemical shift evolution compensation for delays flanked by hard or soft pulses
Chemical shift evolution compensation for delays flanked by hard or soft pulses
Hello all,In a typical 2D experiment, the delay "d0" (t1 increment delay in Bruker) is compensated for the chemical shift evolution that would happen during the rf pulse (hard/soft) that are applied flanking (before and after) the "d0" delay.
I could also find similar such compensations for shaped pulses before a delay in the pulse programs. These compensation factors varies for different types of pulses, e.g. 2/pi for 90 hard pulse , 0.52 for pc490120. Can someone guide me how these compensation factors...
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News from other NMR forums
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08-02-2012 10:48 PM
[NMR paper] NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus interna
NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus internal ribosome entry site: a single C to U substitution drastically changes the shape and flexibility of RNA.
Related Articles NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus internal ribosome entry site: a single C to U substitution drastically changes the shape and flexibility of RNA.
Biochemistry. 2004 May 18;43(19):5757-71
Authors: Du Z, Ulyanov NB, Yu J, Andino R, James TL
The 5'-untranslated region of positive-strand RNA viruses...
Chemical evolution of antivirals against enterovirus D68 through protein-templated Knoevenagel reactions
Linear Mode
