NMR paper Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

		BioNMR > Educational resources > Journal club
[NMR paper] Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-08-2021, 03:00 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

Angewandte Chemie International Edition, EarlyView.

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
[ASAP] Protein Polymerization as a Novel Targeted Protein Degradation Mechanism Protein Polymerization as a Novel Targeted Protein Degradation Mechanism https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.1c00163/20210324/images/medium/bi1c00163_0002.gif Biochemistry DOI: 10.1021/acs.biochem.1c00163 http://feeds.feedburner.com/~r/acs/bichaw/~4/M4WwqAV_fUM More...	nmrlearner	Journal club	0	03-24-2021 11:20 PM
[NMR paper] Increasing nitroxide lifetime in cells to enable in-cell protein structure and dynamics measurements by electron spin resonance spectroscopy Increasing nitroxide lifetime in cells to enable in-cell protein structure and dynamics measurements by electron spin resonance spectroscopy Publication date: February 2019 Source: Journal of Magnetic Resonance, Volume 299 Author(s): Kevin Singewald, Matthew J. Lawless, Sunil Saxena Abstract	nmrlearner	Journal club	0	01-07-2019 05:49 AM
[NMR paper] Real Time In-cell NMR: Ribosome Targeted Antibiotics Modulate Quinary Protein Interactions. Real Time In-cell NMR: Ribosome Targeted Antibiotics Modulate Quinary Protein Interactions. Real Time In-cell NMR: Ribosome Targeted Antibiotics Modulate Quinary Protein Interactions. Biochemistry. 2017 Dec 21;: Authors: Breindel LM, DeMott CM, Burz DS, Shekhtman A Abstract It is not well understood how ribosome antibiotics affect a wide range of biochemical pathways; changes in RNA-mediated protein quinary interactions and consequent activity inside the crowded cytosol may provide one possible mechanism. We developed real-time...	nmrlearner	Journal club	0	12-22-2017 07:55 PM
Alzheimer's Tau protein forms toxic complexes with cell membranes - Science Daily <img alt="" height="1" width="1"> Alzheimer's Tau protein forms toxic complexes with cell membranes Science Daily In collaboration with Professor David Eliezer at Weill Cornell School of Medical Sciences in New York, the researchers used Nuclear Magnetic Resonance (NMR) to gain insight into the structure of Tau in the core of the complexes. This revealed that the ... Alzheimer's Tau protein forms toxic complexes with cell membranes - Science Daily More...	nmrlearner	Online News	0	11-25-2017 09:30 PM
Alzheimer's Tau protein forms toxic complexes with cell membranes - Medical Xpress Alzheimer's Tau protein forms toxic complexes with cell membranes - Medical Xpress http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcR6fTPk3bLO1lcSBmyfm0L1ZBHdmb3xbrT8kkWOZXO6tNpmHSv8laNkcaVHA4gjG3vy55UZ-5k Medical Xpress <img alt="" height="1" width="1"> Alzheimer's Tau protein forms toxic complexes with cell membranes Medical Xpress The brains of patients with Alzheimer's disease contain characteristic tangles inside neurons. These tangles are formed when a protein called Tau aggregates into twisted fibrils. As a result, the neurons' transport systems ... and more »	nmrlearner	Online News	0	11-22-2017 02:01 PM
Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization #DNPNMR From The DNP-NMR Blog: Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization #DNPNMR p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica} Viennet, T., et al., Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization. Angew Chem Int Ed Engl, 2016. 55(36): p. 10746-50.Viennet, T., et al., Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization. Angew Chem Int Ed Engl, 2016. 55(36): p. 10746-50. ...	nmrlearner	News from NMR blogs	0	11-19-2016 08:35 PM
[NMR paper] Cell-compatible, integrin-targeted cryptophane-(129)Xe NMR biosensors. Cell-compatible, integrin-targeted cryptophane-(129)Xe NMR biosensors. Related Articles Cell-compatible, integrin-targeted cryptophane-(129)Xe NMR biosensors. Chem Sci. 2011 Jun;2(6):1103-1110 Authors: Seward GK, Bai Y, Khan NS, Dmochowski IJ Abstract Peptide-modified cryptophane enables sensitive detection of protein analytes using hyperpolarized (129)Xe NMR spectroscopy. Here we report improved targeting and delivery of cryptophane to cells expressing ?v?3 integrin receptor, which is overexpressed in many human cancers....	nmrlearner	Journal club	0	11-06-2014 08:45 PM
[NMR paper] Two-dimensional NMR spectroscopy reveals cation-triggered backbone degradation in polysulfone-based anion exchange membranes. Two-dimensional NMR spectroscopy reveals cation-triggered backbone degradation in polysulfone-based anion exchange membranes. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-custom-pnas_full.gif Related Articles Two-dimensional NMR spectroscopy reveals cation-triggered backbone degradation in polysulfone-based anion exchange membranes. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2490-5 Authors: Arges CG, Ramani V Abstract Anion exchange membranes (AEMs) find...	nmrlearner	Journal club	0	04-09-2013 06:31 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off