Over the last 40 years nuclear magnetic resonance (NMR) spectroscopy has established itself as one of the most versatile techniques for the characterization of biomolecules, especially proteins. Given the molecular size limitations of NMR together with recent advances in cryo-electron microscopy and artificial intelligence-assisted protein structure prediction, the bright future of NMR in structural biology has been put into question. In this mini review we argue the contrary. We discuss the...
[NMR paper] NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology.
NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology.
Methods Mol Biol. 2018;1688:1-35
Authors: Quinn CM, Wang M, Polenova T
Abstract
As a result of profound gains in...
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11-21-2017 10:10 PM
[NMR paper] Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.
Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.
Related Articles Beyond Structural Biology to Functional Biology: Solid-State NMR Experiments and Strategies for Understanding the M2 Proton Channel Conductance.
J Phys Chem B. 2017 Apr 20;:
Authors: Qin H, Miao Y, Cross TA, Fu R
Abstract
In terms of structural biology, solid-state NMR experiments and strategies have been well established for resonance assignments leading to the...
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[NMR paper] Recombinant Intrinsically Disordered Proteins for NMR: Tips and Tricks.
Recombinant Intrinsically Disordered Proteins for NMR: Tips and Tricks.
Related Articles Recombinant Intrinsically Disordered Proteins for NMR: Tips and Tricks.
Adv Exp Med Biol. 2015;870:187-213
Authors: Calçada EO, Korsak M, Kozyreva T
Abstract
The growing recognition of the several roles that intrinsically disordered proteins play in biology places an increasing importance on protein sample availability to allow the characterization of their structural and dynamic properties. The sample preparation is therefore the limiting...
[NMR900 blog] Stable Isotopes for Structural Biomolecular NMR
Stable Isotopes for Structural Biomolecular NMR
Cambridge Isotope Laboratories (CIL) made available a series of application notes on the use of stable isotopes in Biomolecular NMR. These application notes were written by some of the world's leading researches in the field, including several Canadian scientists.
Lewis Kay (University of Toronto) "Alanine Probes of Supra-Molecular Structure and Dynamics", page 9.
Leonid S. Brown and Vladimir Ladizhansky (University of Guelph) "Pichia pastoris as a Eukaryotic Protein Isotope-Labeling System", pages 14-15.
Ying Fan, Lichi Shi,...
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07-22-2011 10:39 PM
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
The New York Structural Biology Center (NYSBC) seeks an experienced electron microscopist to join the staff of its Cryo-Electron Microscope Facility (http://cryoem.nysbc.org). The NYSBC is shared center that supports state-of-the-art research in cryo-EM, NMR, and X-ray. Cryo-EM facilities include four transmission electron microscopes and a new d...
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Biomolecular NMR in the AI-assisted structural biology era: Old tricks and new opportunities
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