Related ArticlesBiological findings from the recent NMR-based studies of glycosaminoglycanprotein interactions.
Glycobiology. 2014 Jun 27;
Authors: Pomin VH
Abstract
Besides regulating multiple physiological processes like cellular growth, migration and differentiation, glycosaminoglycans (GAGs) are also largely explored in the global market as clinical or nutraceutical agents. Generally, these physiological and biomedical events are ultimately triggered by the quality and nature of molecular interactions between GAGs and functional proteins. Nuclear magnetic resonance (NMR) spectroscopy participates significantly in the investigations of the most carbohydrate-protein interactions. The present review covers in a very systematic and comprehensive way the major NMRbased works of GAG-protein interactions undertaken within the last three years. The main objective herein is, besides revisiting the results from these recent NMR-based GAG-protein works, to present for the current glycomic era an overview about the underlying biological inferences drawn from these results.
PMID: 24973916 [PubMed - as supplied by publisher]
[NMR paper] Using 19F NMR to Probe Biological Interactions of Proteins and Peptides.
Using 19F NMR to Probe Biological Interactions of Proteins and Peptides.
Related Articles Using 19F NMR to Probe Biological Interactions of Proteins and Peptides.
ACS Chem Biol. 2014 Apr 24;
Authors: Marsh EN, Suzuki Y
Abstract
Fluorine is a valuable probe for investigating the interactions of biological molecules because of its favorable NMR characteristics, its small size and its near total absence from biology. Advances in biosynthetic methods allow fluorine to be introduced into peptides and proteins with high precision, and...
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[NMR paper] Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties.
Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties.
Related Articles Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties.
Chemistry. 2013 Nov 21;
Authors: Ramos-Soriano J, Niss U, Angulo J, Angulo M, Moreno-Vargas AJ, Carmona AT, Ohlson S, Robina I
Abstract
The synthesis of several non-carbohydrate ligands of cholera toxin...
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11-23-2013 05:08 PM
[NMR paper] NMR-based analysis of protein-ligand interactions.
NMR-based analysis of protein-ligand interactions.
NMR-based analysis of protein-ligand interactions.
Anal Bioanal Chem. 2013 Apr 18;
Authors: Cala O, Guillière F, Krimm I
Abstract
Physiological processes are mainly controlled by intermolecular recognition mechanisms involving protein-protein and protein-ligand (low molecular weight molecules) interactions. One of the most important tools for probing these interactions is high-field solution nuclear magnetic resonance (NMR) through protein-observed and ligand-observed experiments, where...
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04-18-2013 10:12 PM
Recent Studies by G. Brancolini and Co-Authors Add New Data to ... - Equities.com
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Recent Studies by G. Brancolini and Co-Authors Add New Data to ...
Equities.com
Ubiquitin is a small, cysteine-free protein (ubiquitous in eukaryotes) whose binding to gold nanoparticles has been characterized recently by nuclear magnetic resonance (NMR). To reveal the molecular basis of these protein-nanoparticle interactions, we ...
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Recent Studies by G. Brancolini and Co-Authors Add New Data to ... - Equities.com
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Recent Developments in (15)N NMR Relaxation Studies that Probe Protein Backbone Dynamics.
Recent Developments in (15)N NMR Relaxation Studies that Probe Protein Backbone Dynamics.
Recent Developments in (15)N NMR Relaxation Studies that Probe Protein Backbone Dynamics.
Top Curr Chem. 2011 Sep 7;
Authors: Ishima R
Abstract
Nuclear Magnetic Resonance (NMR) relaxation is a powerful technique that provides information about internal dynamics associated with configurational energetics in proteins, as well as site-specific information involved in conformational equilibria. In particular, (15)N relaxation is a useful probe to...
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09-08-2011 06:50 PM
1H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems
1H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems
Abstract The application of metabolomics to human and animal model systems is poised to provide great insight into our understanding of disease etiology and the metabolic changes that are associated with these conditions. However, metabolomic studies have also revealed that there is significant, inherent biological variation in human samples and even in samples from animal model systems where the animals are housed under carefully controlled conditions. This inherent biological...
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03-03-2011 02:06 AM
[NMR paper] NMR-based structural characterization of large protein-ligand interactions.
NMR-based structural characterization of large protein-ligand interactions.
Related Articles NMR-based structural characterization of large protein-ligand interactions.
J Biomol NMR. 2002 Feb;22(2):165-73
Authors: Pellecchia M, Meininger D, Dong Q, Chang E, Jack R, Sem DS
Genomic research on target identification and validation has created a great need for methods that rapidly provide detailed structural information on protein-ligand interactions. We developed a suite of NMR experiments as rapid and efficient tools to provide descriptive...
Biological findings from the recent NMR-based studies of glycosaminoglycanprotein interactions.
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