Binding Sites of a PET Ligand in Tau Fibrils with the Alzheimer's Disease Fold from (19)F and (13)C Solid-State NMR
 

Binding Sites of a PET Ligand in Tau Fibrils with the Alzheimer's Disease Fold from (19)F and (13)C Solid-State NMR

Aggregation of the tau protein into cross-? amyloid fibrils is a hallmark of Alzheimer's disease (AD) and many other neurodegenerative disorders. Developing small molecules that bind these tau fibrils is important for the diagnosis and treatment of tauopathies. Here, we report the binding sites of a positron emission tomography (PET) ligand, PI-2620, to a recombinant tau construct that adopts the C-shaped AD fold. Using solid-state NMR ^(13)C-^(19)F rotational-echo double-resonance (REDOR)...

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