Intravenous gallium nitrate therapy is a novel therapeutic strategy deployed to combat chronic Pseudomonas aeruginosa biofilm infections in the lungs of cystic fibrosis (CF) patients by interfering with iron (Fe^(3+)) uptake. The therapy is a source of Ga^(3+), which competes with Fe^(3+) for siderophore binding, subsequently disrupting iron metabolism and inhibiting biofilm proliferation in vivo. It was recently demonstrated that the Pseudomonas quinolone signal (PQS) can chelate Fe^(3+) to...
[NMR paper] 1H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol.
1H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol.
Related Articles 1H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol.
J Proteome Res. 2017 Jan 17;:
Authors: Chen T, Sheng J, Fu Y, Li MH, Wang JS, Jia A
Abstract
Quorum sensing (QS) is a process of bacterial communication that has been a novel target for drug discovery. Pyocyanin quantification assay confirmed that resveratrol was an...
nmrlearner
Journal club
0
01-19-2017 08:56 AM
[NMR paper] Multivalent ligand mimetics of LecA from P. aeruginosa: synthesis and NMR studies.
Multivalent ligand mimetics of LecA from P. aeruginosa: synthesis and NMR studies.
Related Articles Multivalent ligand mimetics of LecA from P. aeruginosa: synthesis and NMR studies.
Carbohydr Res. 2016 Apr 28;
Authors: Bini D, Marchetti R, Russo L, Molinaro A, Silipo A, Cipolla L
Abstract
Molecular recognition of glycans plays an important role in glycomic and glycobiology studies. For example, pathogens have a number of different types of lectin for targeting host sugars. In bacteria, lectins exist sometimes as domains of...
nmrlearner
Journal club
0
05-18-2016 09:53 PM
Liquid state DNP at high magnetic fields: Instrumentation, experimental results and atomistic modelling by molecular dynamics simulations
From The DNP-NMR Blog:
Liquid state DNP at high magnetic fields: Instrumentation, experimental results and atomistic modelling by molecular dynamics simulations
Prisner, T., V. Denysenkov, and D. Sezer, Liquid state DNP at high magnetic fields: Instrumentation, experimental results and atomistic modelling by molecular dynamics simulations. J Magn Reson, 2016. 264: p. 68-77.
http://www.ncbi.nlm.nih.gov/pubmed/26920832
nmrlearner
News from NMR blogs
0
05-05-2016 03:15 AM
[NMR paper] NMR Characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa.
NMR Characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa.
Related Articles NMR Characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa.
Biochemistry. 2015 Oct 9;
Authors: Chaudhury S, Nordhues BA, Kaur K, Zhang N, De Guzman RN
Abstract
Lung infection with Pseudomonas aeruginosa is the leading cause of death among cystic fibrosis patients. To initiate infection, P. aeruginosa assembles a protein nanomachine, the type III secretion...
nmrlearner
Journal club
0
10-10-2015 06:47 PM
[NMR paper] Sliding and target location of DNA-binding proteins:an NMR view of the lac repressor system.
Sliding and target location of DNA-binding proteins:an NMR view of the lac repressor system.
Related Articles Sliding and target location of DNA-binding proteins:an NMR view of the lac repressor system.
J Biomol NMR. 2013 Apr 9;
Authors: Loth K, Gnida M, Romanuka J, Kaptein R, Boelens R
Abstract
In non-specific lac headpiece-DNA complexes selective NMR line broadening is observed that strongly depends on length and composition of the DNA fragments. This broadening involves amide protons found in the non-specific lac-DNA structure to be...
Atomistic modelling and NMR studies reveal that gallium can target the ferric PQS uptake system in P. aeruginosa biofilms
Linear Mode
