Related ArticlesAssessment of dietary exposure and effect in humans: The role of NMR.
Prog Nucl Magn Reson Spectrosc. 2016 08;96:58-72
Authors: van Duynhoven JP, Jacobs DM
Abstract
In human nutritional science progress has always depended strongly on analytical measurements for establishing relationships between diet and health. This field has undergone significant changes as a result of the development of NMR and mass spectrometry methods for large scale detection, identification and quantification of metabolites in body fluids. This has allowed systematic studies of the metabolic fingerprints that biological processes leave behind, and has become the research field of metabolomics. As a metabolic profiling technique, NMR is at its best when its unbiased nature, linearity and reproducibility are exploited in well-controlled nutritional intervention and cross-sectional population screening studies. Although its sensitivity is less good than that of mass spectrometry, NMR has maintained a strong position in metabolomics through implementation of standardisation protocols, hyphenation with mass spectrometry and chromatographic techniques, accurate quantification and spectral deconvolution approaches, and high-throughput automation. Thus, NMR-based metabolomics has contributed uniquely to new insights into dietary exposure, in particular by unravelling the metabolic fates of phytochemicals and the discovery of dietary intake markers. NMR profiling has also contributed to the understanding of the subtle effects of diet on central metabolism and lipoprotein metabolism. In order to hold its ground in nutritional metabolomics, NMR will need to step up its performance in sensitivity and resolution; the most promising routes forward are the analytical use of dynamic nuclear polarisation and developments in microcoil construction and automated fractionation.
[NMR paper] Effect of organochlorine pesticides exposure on the maize root metabolome assessed using high-resolution magic-angle spinning (1)H NMR spectroscopy.
Effect of organochlorine pesticides exposure on the maize root metabolome assessed using high-resolution magic-angle spinning (1)H NMR spectroscopy.
Effect of organochlorine pesticides exposure on the maize root metabolome assessed using high-resolution magic-angle spinning (1)H NMR spectroscopy.
Environ Pollut. 2016 Apr 28;214:539-548
Authors: Blondel C, Khelalfa F, Reynaud S, Fauvelle F, Raveton M
Abstract
(1)H-HRMAS NMR-based metabolomics was used to better understand the toxic effects on maize root tips of...
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05-02-2016 11:33 AM
Assessment of dietary exposure and effect in humans: The role of NMR
Assessment of dietary exposure and effect in humans: The role of NMR
Publication date: Available online 6 April 2016
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): John P.M. van Duynhoven, Doris M. Jacobs</br>
In human nutritional science progress has always depended strongly on analytical measurements for establishing relationships between diet and health. This field has undergone significant changes as a result of the development of NMR and mass spectrometry methods for large scale detection, identification and quantification of...
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04-09-2016 03:54 AM
Dynamic nuclear polarization and Hanle effect in (In,Ga)As/GaAs quantum dots. Role of nuclear spin fluctuations
From The DNP-NMR Blog:
Dynamic nuclear polarization and Hanle effect in (In,Ga)As/GaAs quantum dots. Role of nuclear spin fluctuations
Gerlovin, I.Y., et al., Dynamic nuclear polarization and Hanle effect in (In,Ga)As/GaAs quantum dots. Role of nuclear spin fluctuations. AIP Conference Proceedings, 2013. 1566(1): p. 319-320.
http://scitation.aip.org/content/aip/proceeding/aipcp/10.1063/1.4848414
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12-06-2014 04:54 AM
Dynamic nuclear polarization and Hanle effect in (In,Ga)As/GaAs quantum dots. Role of nuclear spin fluctuations
From The DNP-NMR Blog:
Dynamic nuclear polarization and Hanle effect in (In,Ga)As/GaAs quantum dots. Role of nuclear spin fluctuations
Gerlovin, I.Y., et al., Dynamic nuclear polarization and Hanle effect in (In,Ga)As/GaAs quantum dots. Role of nuclear spin fluctuations. AIP Conference Proceedings, 2013. 1566(1): p. 319-320.
http://scitation.aip.org/content/aip/proceeding/aipcp/10.1063/1.4848414
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11-18-2014 01:39 AM
Journal Highlight: Rapid assessment of the illegal presence of 1,3-dimethylamylamine (DMAA) in sports nutrition and dietary supplements using 1H NMR spectroscopy
Journal Highlight: Rapid assessment of the illegal presence of 1,3-dimethylamylamine (DMAA) in sports nutrition and dietary supplements using 1H NMR spectroscopy
http://www.spectroscopynow.com/common/images/thumbnails/14898526bb5.jpgA proton NMR method was developed and validated for measuring 1,3-dimethylamylamine in sports nutrition and dietary supplements and is recommended for routine use in food testing, customs or doping control laboratories.
Read the rest at Spectroscopynow.com
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10-06-2014 12:37 PM
Spin dynamic simulations of solid effect DNP: the role of the relaxation superoperator
From The DNP-NMR Blog:
Spin dynamic simulations of solid effect DNP: the role of the relaxation superoperator
Karabanov, A., G. Kwiatkowski, and W. Köckenberger, Spin dynamic simulations of solid effect DNP: the role of the relaxation superoperator. Mol. Phys., 2014: p. 1-17.
http://dx.doi.org/10.1080/00268976.2014.884287
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07-09-2014 05:07 PM
The Role of the Interaction Frame in the Theoretical Description of Solid Effect Dynamic Nuclear Polarization
From The DNP-NMR Blog:
The Role of the Interaction Frame in the Theoretical Description of Solid Effect Dynamic Nuclear Polarization
Kwiatkowski, G., A. Karabanov, and W. Köckenberger, The Role of the Interaction Frame in the Theoretical Description of Solid Effect Dynamic Nuclear Polarization. Israel Journal of Chemistry, 2014. 54(1-2): p. 184-195.
http://dx.doi.org/10.1002/ijch.201300125
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04-30-2014 02:21 PM
A 1H NMR metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regeneration after partial hepatectomy
A 1H NMR metabolic profiling to the assessment of protein tyrosine phosphatase 1B role in liver regeneration after partial hepatectomy
Available online 12 December 2012
Publication year: 2012
Source:Biochimie</br>
</br>
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the tyrosine kinase growth factor signaling pathway, which is involved in major physiological mechanisms such as liver regeneration. We investigate early hepatic metabolic events produced by partial hepatectomy (PHx) for PTP1B deficient (PTP1B KO) and wild type (WT) mice using proton...
Assessment of dietary exposure and effect in humans: The role of NMR.
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