Related ArticlesApplication of NMR in structural proteomics: screening for proteins amenable to structural analysis.
Structure. 2002 Dec;10(12):1613-8
Authors: Rehm T, Huber R, Holak TA
In the time of structural proteomics when protein structures are targeted on a genome-wide scale, the detection of "well-behaved" proteins that would yield good quality NMR spectra or X-ray images is the key to high-throughput structure determination. Already, simple one-dimensional proton NMR spectra provide enough information for assessing the folding properties of proteins. Heteronuclear two-dimensional spectra are routinely used for screenings that reveal structural, as well as binding, properties of proteins. NMR can thus provide important information for optimizing conditions for protein constructs that are amenable to structural studies.
[NMR paper] NMR for structural proteomics of Thermotoga maritima: screening and structure determi
NMR for structural proteomics of Thermotoga maritima: screening and structure determination.
Related Articles NMR for structural proteomics of Thermotoga maritima: screening and structure determination.
J Struct Funct Genomics. 2004;5(3):205-15
Authors: Peti W, Etezady-Esfarjani T, Herrmann T, Klock HE, Lesley SA, Wüthrich K
This paper describes the NMR screening of 141 small (
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[NMR paper] Application of NMR SHAPES screening to an RNA target.
Application of NMR SHAPES screening to an RNA target.
Related Articles Application of NMR SHAPES screening to an RNA target.
J Am Chem Soc. 2003 Dec 24;125(51):15724-5
Authors: Johnson EC, Feher VA, Peng JW, Moore JM, Williamson JR
Several NMR screening techniques have been developed in recent years to aid in the identification of lead drug compounds. These NMR methods have traditionally been used for protein targets, and here we examine their applicability for an RNA target. We used the SHAPES compound library to test three different NMR...
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[NMR paper] Leveraging structural approaches: applications of NMR-based screening and X-ray cryst
Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.
Related Articles Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.
J Synchrotron Radiat. 2004 Jan 1;11(Pt 1):97-100
Authors: Moore J, Abdul-Manan N, Fejzo J, Jacobs M, Lepre C, Peng J, Xie X
In the last several years, NMR strategies in drug discovery have evolved from a primarily structural focus to a set of technologies that are non-structural in nature but...
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[NMR paper] High-throughput screening of structural proteomics targets using NMR.
High-throughput screening of structural proteomics targets using NMR.
Related Articles High-throughput screening of structural proteomics targets using NMR.
FEBS Lett. 2003 Sep 25;552(2-3):207-13
Authors: Galvão-Botton LM, Katsuyama AM, Guzzo CR, Almeida FC, Farah CS, Valente AP
We applied a high-throughput strategy for the screening of targets for structural proteomics of Xanthomonas axonopodis pv citri. This strategy is based on the rapid (1)H-(15)N HSQC NMR analysis of bacterial lysates containing selectively (15)N-labelled heterologous...
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[NMR paper] An NMR approach to structural proteomics.
An NMR approach to structural proteomics.
Related Articles An NMR approach to structural proteomics.
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1825-30
Authors: Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH
The influx of genomic sequence information has led to the concept of structural proteomics, the determination of protein structures on a...
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Chemical shift tensors: Theory and application to molecular structural problems
Chemical shift tensors: Theory and application to molecular structural problems
Publication year: 2010
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 22 October 2010</br>
Julio C., Facelli</br>
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NMR in structural proteomics and beyond.
NMR in structural proteomics and beyond.
Related Articles NMR in structural proteomics and beyond.
Prog Nucl Magn Reson Spectrosc. 2010 Apr;56(3):247-66
Authors: Banci L, Bertini I, Luchinat C, Mori M
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[NMR paper] Application of neural networks to automated assignment of NMR spectra of proteins.
Application of neural networks to automated assignment of NMR spectra of proteins.
Related Articles Application of neural networks to automated assignment of NMR spectra of proteins.
J Biomol NMR. 1994 Jan;4(1):35-46
Authors: Hare BJ, Prestegard JH
Simulated neural networks are described which aid the assignment of protein NMR spectra. A network trained to recognize amino acid type from TOCSY data was trained on 148 assigned spin systems from E. coli acyl carrier proteins (ACPs) and tested on spin systems from spinach ACP, which has a 37%...
Application of NMR in structural proteomics: screening for proteins amenable to struc
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