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Old 09-19-2010, 03:08 AM
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Default Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in th

Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist.

Related Articles Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist.

J Pharm Biomed Anal. 2010 Nov 2;53(3):389-95

Authors: Provera S, Martini L, Guercio G, Turco L, Costa L, Marchioro C

Vestipitant (1) is a novel NK1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The first synthetic step comprised a Grignard synthesis. An impurity was identified and initially expected to be a symmetric biphenyl. This paper reports the work to synthesise the supposed structure and the spectroscopic analyses (LC-NMR and HR-NMR) to correctly identify the real structure and understand the chemical pathway of the impurity.

PMID: 20478677 [PubMed - indexed for MEDLINE]



Source: PubMed
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