Apoptosis Inducing Factor Binding Protein PGAM5 TriggersMitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activityof X-Linked Inhibitor of Apoptosis
Apoptosis Inducing Factor Binding Protein PGAM5 TriggersMitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activityof X-Linked Inhibitor of Apoptosis
[NMR paper] A novel 2-oxoindolinylidene inhibitor of bacterial MurD ligase: Enzyme kinetics, protein-inhibitor binding by NMR and a molecular dynamics study.
A novel 2-oxoindolinylidene inhibitor of bacterial MurD ligase: Enzyme kinetics, protein-inhibitor binding by NMR and a molecular dynamics study.
Related Articles A novel 2-oxoindolinylidene inhibitor of bacterial MurD ligase: Enzyme kinetics, protein-inhibitor binding by NMR and a molecular dynamics study.
Eur J Med Chem. 2014 Jun 11;83C:92-101
Authors: Sim?i? M, Pureber K, Kristan K, Urleb U, Kocjan D, Grdadolnik SG
Abstract
N-(5-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)4-oxo-2-thioxo-1,3-thiazolidin-3-yl)nicotinamide,...
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06-22-2014 12:24 PM
A Novel 2-oxoindolinylidene Inhibitor of Bacterial MurD Ligase: Enzyme Kinetics, Protein-Inhibitor Binding by NMR and a Molecular Dynamics Study
A Novel 2-oxoindolinylidene Inhibitor of Bacterial MurD Ligase: Enzyme Kinetics, Protein-Inhibitor Binding by NMR and a Molecular Dynamics Study
Publication date: Available online 11 June 2014
Source:European Journal of Medicinal Chemistry</br>
Author(s): Mihael Sim?i? , Kaja Pureber , Katja Kristan , Uroš Urleb , Darko Kocjan , Simona Goli? Grdadolnik</br>
N-(5-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)4-oxo-2-thioxo-1,3-thiazolidin-3-yl)nicotinamide, an 2-oxoindolinylidene derivative with novel structure scaffold, was evaluated for inhibition potency...
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06-12-2014 10:52 PM
[NMR paper] PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.nature.com-images-npg_logo.gif Related Articles PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat Chem Biol. 2013 Jan 20;
Authors: Follis AV, Chipuk JE, Fisher JC, Yun MK, Grace CR, Nourse A, Baran K, Ou L, Min L, White SW, Green DR, Kriwacki RW
Abstract
Following DNA damage, nuclear p53 induces the expression of PUMA, a BH3-only...
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02-03-2013 10:19 AM
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A
Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A
Abstract Ube3A (also referred to as E6AP for E6 Associated Protein) is a E3 ubiquitin-protein ligase implicated in the development of Angelman syndrome by controlling degradation of synaptic protein Arc and oncogenic papilloma virus infection by controlling degradation of p53. This article describe the solution NMR structure of the conserved N-terminal domain of human Ube3A (residues 24-87) that contains two residues (Cys44 and Arg62) found to be mutated in patients with Angelman syndrome. The structure of this domain...
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09-30-2011 08:01 PM
[NMR paper] NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
Related Articles NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
Structure. 2003 Oct;11(10):1199-205
Authors: Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grütter MG, Wüthrich K
Signaling in apoptosis and inflammation is often mediated by proteins of the death domain superfamily in the Fas/FADD/Caspase-8 or the Apaf-1/Caspase-9 pathways. This superfamily currently comprises the death domain (DD), death effector domain...
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11-24-2010 09:16 PM
[NMR paper] NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis p
NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
Related Articles NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J Biol Chem. 2000 Oct 27;275(43):33777-81
Authors: Sun C, Cai M, Meadows RP, Xu N, Gunasekera AH, Herrmann J, Wu JC, Fesik SW
The inhibitor of apoptosis proteins (IAPs) regulate the caspase family of cysteine proteases, which play an important role in the execution of programmed cell death. Human X-linked inhibitor of apoptosis...
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11-19-2010 08:29 PM
[NMR paper] NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
Related Articles NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
Nature. 1999 Oct 21;401(6755):818-22
Authors: Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW
The inhibitor-of-apoptosis (IAP) family of proteins, originally identified in baculoviruses, regulate programmed cell death in a variety of organisms. IAPs inhibit specific enzymes (caspases) in the death cascade and contain one to three...
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11-18-2010 08:31 PM
[NMR paper] 13C-NMR investigation of protein synthesis during apoptosis in human leukemic cell li
13C-NMR investigation of protein synthesis during apoptosis in human leukemic cell lines.
Related Articles 13C-NMR investigation of protein synthesis during apoptosis in human leukemic cell lines.
J Cell Physiol. 1999 Oct;181(1):147-52
Authors: Scott CE, Adebodun F
In order to evaluate the role of protein synthesis in apoptosis, (13)C-NMR has been used to study the levels of protein synthesis in three different human leukemic cell lines in the presence and absence of dexamethasone-induced apoptosis. Measurements were done on one...
Apoptosis Inducing Factor Binding Protein PGAM5 TriggersMitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activityof X-Linked Inhibitor of Apoptosis
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