Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe FPPA
 

Adenosine A2A Receptor (A2AAR) Ligand Screening Using the 19F-NMR Probe FPPA

The binding affinity of G protein-coupled receptor (GPCR) ligands is customarily measured by radio-ligand competition experiments. As an alternative approach, ^(19)F nuclear magnetic resonance spectroscopy (^(19)F-NMR) is used for the screening of small-molecule lead compounds in drug discovery; the two methods are complementary in that the measurements are performed with widely different experimental conditions. Here, we used the structure of the A(2A) adenosine receptor (A(2A)AR) complex with...

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