With the ability to determine atomic resolution structures of biological macromolecules in semi-physiological conditions, nuclear magnetic resonance spectroscopy (NMR) has become an eminent tool in structural biology. NMR provides a means for studying critical biological phenomena including protein structure, dynamics and folding as well as a practical approach to drug design.
Postoctoral position in Structural Biology
Postoctoral position in Structural Biology
UNIVERSITY OF OXFORD
DEPARTMENT OF BIOCHEMISTRY
Postdoctoral Research Associate in Structural Biology
We are seeking to appoint a highly motivated Postdoctoral Research
Associate in the laboratory of Dr. Ioannis Vakonakis for studies of
proteins involved in centriole assembly. The successful candidate will
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
The New York Structural Biology Center (NYSBC) seeks an experienced electron microscopist to join the staff of its Cryo-Electron Microscope Facility (http://cryoem.nysbc.org). The NYSBC is shared center that supports state-of-the-art research in cryo-EM, NMR, and X-ray. Cryo-EM facilities include four transmission electron microscopes and a new d...
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Structural Biology Scores With Protein Snapshot
Structural Biology Scores With Protein Snapshot
(July 12, 2009) -- Investigators have used nuclear magnetic resonance methods to determine the structure of the largest membrane-spanning protein to date. The group's ability to determine the NMR structure of the bacterial protein diacylglycerol kinase, reported in the journal Science, suggests that similar methods can now be used to study the stru
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nmrlearner
Online News
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08-19-2010 01:47 PM
Prospects for lanthanides in structural biology by NMR
Prospects for lanthanides in structural biology by NMR
Gottfried Otting
Journal of Biomolecular NMR; 2008; 42(1); pp 1-9
Abstract:
The advent of different lanthanide-binding reagents has made site-specific labelling of proteins with paramagnetic lanthanides a viable proposition. This brings many powerful techniques originally established and demonstrated for paramagnetic metalloproteins into the mainstream of structural biology. The promise is that, by exploiting the long-range effects of paramagnetism, lanthanide labelling will allow the study of larger proteins and protein–ligand...
Brian
Journal club
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09-17-2008 10:12 PM
Another lecture by Gregg Siegal - NMR and Structural Biology
Gregg Siegal (Leiden Institute of Chemistry) discusses the application of NMR to structural biology.
http://metprot.lic.gorlaeus.net/siegal/teaching/struc_biol/NMR_and_Structural_Biology.ppt
The website of the LIC's protein chemistry department can be found here:
http://protchem.lic.gorlaeus.net/index.php?nav=home