[NMR paper] 1H-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats.
Related Articles1H-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats.
Metabolites. 2020 Apr 21;10(4):
Authors: Viana LR, Lopes-Aguiar L, Rossi Rosolen R, Willians Dos Santos R, Cintra Gomes-Marcondes MC
Abstract
Sarcopenia among the older population has been growing over the last few years. In addition, the incidence of cancers increases with age and, consequently, the development of cachexia related cancer. Therefore, the elucidation of the metabolic derangements of sarcopenia and cachexia are important to improve the survival and life quality of cancer patients. We performed the 1H-NMR based serum metabolomics in adult (A) and ageing (S) Walker 256 tumour-bearing rats in different stages of tumour evolution, namely intermediated (Wi) and advanced (Wa). Among 52 serum metabolites that were identified, 21 were significantly increased in S and 14 and 19 decreased in the Wi and Wa groups, respectively. The most impacted pathways by this metabolic alteration were related by amino acid biosynthesis and metabolism, with an upregulation in S group and downregulation in Wi and Wa groups. Taken together, our results suggest that the increase in metabolic profile in ageing rats is associated with the higher muscle protein degradation that releases several metabolites, especially amino acids into the serum. On the other hand, we hypothesise that the majority of metabolites released by muscle catabolism are used by tumours to sustain rapid cell proliferation and tumorigenesis.
[NMR paper] Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation.
Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.nature.com-images-lo_npg.gif http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation.
Sci Rep. 2016 11 03;6:36474
...
nmrlearner
Journal club
0
05-15-2018 03:38 PM
[NMR paper] NMR-Based Metabolomics Reveal a Recovery from Metabolic Changes in the Striatum of 6-OHDA-Induced Rats Treated with Basic Fibroblast Growth Factor.
NMR-Based Metabolomics Reveal a Recovery from Metabolic Changes in the Striatum of 6-OHDA-Induced Rats Treated with Basic Fibroblast Growth Factor.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR-Based Metabolomics Reveal a Recovery from Metabolic Changes in the Striatum of 6-OHDA-Induced Rats Treated with Basic Fibroblast Growth Factor.
Mol Neurobiol. 2016 Dec;53(10):6690-6697
Authors: Zheng H, Zhao L, Xia H, Xu C, Wang D, Liu K, Lin L, Li X,...
nmrlearner
Journal club
0
12-31-2017 10:41 AM
[NMR paper] NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics.
NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics.
Related Articles NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics.
Prostate. 2016 Sep;76(12):1106-19
Authors: Kumar D, Gupta A, Mandhani A, Sankhwar SN
Abstract
BACKGROUND: To address the shortcomings of digital rectal examinations (DRE), serum prostate-specific antigen (PSA), and trans-rectal ultrasound (TRUS) for precise determination of prostate cancer (PC) and differentiation from benign prostatic...
nmrlearner
Journal club
0
07-14-2017 01:53 PM
[NMR paper] Early Effect of Amyloid ?-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis.
Early Effect of Amyloid ?-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--images.hindawi.com-linkout-hindawi.button.gif http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Early Effect of Amyloid ?-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and...
nmrlearner
Journal club
0
03-14-2017 10:36 PM
Journal Highlight: NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics
Journal Highlight: NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics
http://www.spectroscopynow.com/common/images/thumbnails/1563b836aed.jpgThe application of 1H NMR spectroscopy of 52 serum metabolites as a surrogate tactic for probing and predicting prostate cancer and benign prostatic hyperplasia is on a par with LC/MS and histopathological examination.
Read the rest at Spectroscopynow.com
nmrlearner
General
0
08-01-2016 10:03 AM
[NMR paper] NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
Mol Biosyst. 2014 Jul 29;10(9):2426-40
Authors: Guo P, Wang J, Dong G, Wei D, Li M, Yang M, Kong L
Abstract
Ricin, a large, water soluble toxic glycoprotein, is distributed...
nmrlearner
Journal club
0
10-16-2015 01:44 PM
[NMR paper] Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Mol Biosyst. 2014 Jan 21;
Authors: Diao C, Zhao L, Guan M, Zheng Y, Chen M, Yang Y, Lin L, Chen W, Gao H
Abstract
Diabetes mellitus is a typical heterogeneous metabolic disorder characterized by abnormal...
nmrlearner
Journal club
0
01-23-2014 03:58 PM
[NMR paper] 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
Chem Biol Interact. 2013 May 25;203(3):588-96
Authors: Wang HP, Liang YJ, Sun YJ, Chen JX,...