GPCRs exhibit a wide range of pharmacological efficacies, yet the molecular mechanisms responsible for the differential efficacies in response to various ligands remain poorly understood. This lack of understanding has hindered the development of a solid foundation for establishing a mathematical model for signaling efficacy. However, recent progress has been made in delineating and quantifying receptor conformational states and associating function with these conformations. This progress has...
[NMR paper] G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling
G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling
G protein-coupled receptors (GPCRs) are a large membrane protein family found in higher organisms, including the human body. GPCRs mediate cellular responses to diverse extracellular stimuli and thus control key physiological functions, which makes them important targets for drug design. Signaling by GPCRs is related to the structure and dynamics of these proteins, which are modulated by extrinsic ligands as well as by...
[ASAP] Dynamic G Protein-Coupled Receptor Signaling Probed by Solution NMR Spectroscopy
Dynamic G Protein-Coupled Receptor Signaling Probed by Solution NMR Spectroscopy
https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.0c00032/20200302/images/medium/bi0c00032_0014.gif
Biochemistry
DOI: 10.1021/acs.biochem.0c00032
http://feeds.feedburner.com/~r/acs/bichaw/~4/4bPBV3Rv0UE
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03-03-2020 11:18 PM
Receptor Activity Modifying Proteins Have LimitedEffects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-LikeReceptor Stalk
Receptor Activity Modifying Proteins Have LimitedEffects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-LikeReceptor Stalk
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b01180/20180207/images/medium/bi-2017-01180k_0008.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b01180
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
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02-08-2018 04:02 AM
Structural Basis for G Protein-Coupled Receptor Activation
Structural Basis for G Protein-Coupled Receptor Activation
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00747/20171010/images/medium/bi-2017-00747c_0005.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00747
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10-10-2017 09:37 PM
[NMR paper] NMR Investigation of Structures of G-Protein Coupled Receptor Folding Intermediates.
NMR Investigation of Structures of G-Protein Coupled Receptor Folding Intermediates.
Related Articles NMR Investigation of Structures of G-Protein Coupled Receptor Folding Intermediates.
J Biol Chem. 2016 Nov 18;:
Authors: Poms M, Ansorge P, Martinez-Gil L, Jurt S, Gottstein D, Fracchiolla KE, Cohen LS, Guentert P, Mingarro I, Naider F, Zerbe O
Abstract
Folding of G-protein coupled receptors (GPCRs) according to the two-stage model (Popot et al., Biochemistry 29(1990), 4031) is postulated to proceed in 2 steps: Partitioning of...
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11-20-2016 09:20 PM
[NMR paper] Constructing a folding model for protein S6 guided by native fluctuations deduced from NMR structures.
Constructing a folding model for protein S6 guided by native fluctuations deduced from NMR structures.
Related Articles Constructing a folding model for protein S6 guided by native fluctuations deduced from NMR structures.
J Chem Phys. 2015 Dec 28;143(24):243141
Authors: Lammert H, Noel JK, Haglund E, Schug A, Onuchic JN
Abstract
The diversity in a set of protein nuclear magnetic resonance (NMR) structures provides an estimate of native state fluctuations that can be used to refine and enrich structure-based protein models...
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01-04-2016 07:49 PM
[NMR paper] Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Sac
Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Saccharomyces cerevisiae tridecapeptide pheromone receptor.
Related Articles Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Saccharomyces cerevisiae tridecapeptide pheromone receptor.
Biopolymers. 1998 Nov;46(6):343-57
Authors: Arshava B, Liu SF, Jiang H, Breslav M, Becker JM, Naider F
Peptides representing both loop and the sixth transmembrane regions of the alpha-factor receptor of Saccharomyces cerevisiae were synthesized by...
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling
Linear Mode
