(1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
Mol Cell Endocrinol. 2016 Jan 7;
Authors: Shen G, Li Z, Zhang Y, Wu H, Feng J
Abstract
In this study, NMR-based metabolomics in combination with multivariate pattern recognition technologies were employed to evaluate the physiological variations in the Wistar rats' plasma that are induced by pregnancy on the gestational days (GDs) 11, 14, 17 and 20. Untargeted metabolomics analysis revealed some possible mechanism of physiological effects for healthy pregnancies and showed a metabolic trajectory during pregnancy process. The levels of 24 metabolites were found to change significantly throughout pregnancy in maternal plasma. These metabolite changes involved in varied kinds of metabolic pathways including synthesis of biological substances, microbial metabolism in diverse environments, protein digestion and absorption, carbohydrate metabolism, digestion and absorption, mineral absorption, and ATP (Adenosine Triphosphate)-binding cassette transporters (ABC transporters). The substantial cores of all the metabolic pathways are promoting fetal growth and development and regulating maternal physiological state. This work showed relevant metabolic pathways perturbation in the maternal plasma due to normal pregnancy and provided the physical basis of time-dependent metabolic trajectory against which disease-related maternal physiological responses may be better understood in future studies.
PMID: 26773731 [PubMed - as supplied by publisher]
[NMR paper] NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
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Mol Biosyst. 2014 Jul 29;10(9):2426-40
Authors: Guo P, Wang J, Dong G, Wei D, Li M, Yang M, Kong L
Abstract
Ricin, a large, water soluble toxic glycoprotein, is distributed...
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[NMR paper] (1)H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus).
(1)H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus).
(1)H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus).
Chemosphere. 2015 Jul 22;138:537-545
Authors: Liu Y, Chen T, Li MH, Xu HD, Jia AQ, Zhang JF, Wang JS
Abstract
Dichlorvos (DDVP), one of the most widely used organophosphorus pesticides (OPs), has caused serious pollution in environment. In this study, (1)H nuclear magnetic resonance (NMR) based metabolomics...
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[NMR paper] Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
J Proteome Res. 2014 Dec 22;
Authors: Pinto J, Barros AS, Domingues MR, Goodfellow BJ, Galhano E, Pita C, Almeida MD, Carreira IM, Gil AM
Abstract
This paper presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy...
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12-23-2014 12:58 PM
[NMR paper] An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.
An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.
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Meat Sci. 2014 Feb;96(2 Pt A):719-28
Authors: Straadt IK, Aaslyng MD, Bertram HC
Abstract
Meat extracts from five different pig crossbreeds including Duroc/Landrace/Yorkshire (DLY),...
Nuclear Magnetic Resonance (NMR)-Based Metabolomics.
Nuclear Magnetic Resonance (NMR)-Based Metabolomics.
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Methods Mol Biol. 2011;708:321-34
Authors: Keun HC, Athersuch TJ
Biofluids are by far the most commonly studied sample type in metabolic profiling studies, encompassing blood, urine, cerebrospinal fluid, cell culture media and many others. A number of these fluids can be obtained at a high sampling frequency with minimal invasion, permitting detailed characterisation of dynamic metabolic events. One of the attractive properties of...
(1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
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