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Structure from chemical shifts:
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Flexibility from chemical shifts:
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Protein geomtery:
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From structure:
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From sequence:
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Disordered proteins:
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Format conversion & validation:
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From NMR-STAR 3.1
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NMR sample preparation:
Protein disorder:
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Protein solubility:
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camGroEL
Zyggregator
Isotope labeling:
UPLABEL
Solid-state NMR:
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Old 07-26-2024, 08:55 PM
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Default (1)H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome

(1)H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome

CONCLUSIONS: Ube3a loss of function alters bioenergy-related metabolism in the AS brain during embryonic development. Furthermore, these neurochemical changes could be linked to the mitochondrial reactive oxygen species and oxidative stress that occurs during the AS embryonic development.

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