[NMR paper] (1)H NMR-based metabolomics analysis of adult zebrafish (Danio rerio) after exposure to diniconazole as well as its bioaccumulation behavior.
Related Articles(1)H NMR-based metabolomics analysis of adult zebrafish (Danio rerio) after exposure to diniconazole as well as its bioaccumulation behavior.
Chemosphere. 2017 Feb;168:1571-1577
Authors: Wang Y, Zhu W, Wang D, Teng M, Yan J, Miao J, Zhou Z
Abstract
As a systemic triazole fungicide, limited information is known about diniconazole. In this study, toxicological effects and bioaccumulation behavior of diniconazole in zebrafish were both evaluated to perform an overall assessment of its environmental risk towards aquatic organisms. The (1)H NMR-based metabolomics analysis revealed that 70*?g*L(-1) diniconazole exposure increased valine, leucine, isoleucine, alanine, lactate and choline, accompanied by decreased glucose, creatine and taurine, in comparison to the control. In the exposure group of 300*?g*L(-1) diniconazole, only down-regulated glucose and creatine were observed. The above results indicated that diniconazole disturbed energy metabolism, amino acid metabolism and lipid metabolism. Histological examination showed that the swell and vacuolization in the liver, as well as the reduction of spermatids in the diniconazole exposure groups. No enantioselectivity was observed in the bioaccumulation process of both 70 and 300*?g*L(-1) diniconazole exposure groups. The above results play a vital role for a comprehensive environmental assessment of diniconazole.
[NMR paper] 1H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol.
1H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol.
Related Articles 1H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol.
J Proteome Res. 2017 Jan 17;:
Authors: Chen T, Sheng J, Fu Y, Li MH, Wang JS, Jia A
Abstract
Quorum sensing (QS) is a process of bacterial communication that has been a novel target for drug discovery. Pyocyanin quantification assay confirmed that resveratrol was an...
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[NMR paper] 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
Chem Biol Interact. 2013 May 25;203(3):588-96
Authors: Wang HP, Liang YJ, Sun YJ, Chen JX,...
NMR-based metabolomics of mammalian cell and tissue cultures
NMR-based metabolomics of mammalian cell and tissue cultures
Abstract NMR spectroscopy was used to evaluate growth media and the cellular metabolome in two systems of interest to biomedical research. The first of these was a Chinese hamster ovary cell line engineered to express a recombinant protein. Here, NMR spectroscopy and a quantum mechanical total line shape analysis were utilized to quantify 30 metabolites such as amino acids, Krebs cycle intermediates, activated sugars, cofactors, and others in both media and cell extracts. The impact of bioreactor scale and addition of...
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Nuclear Magnetic Resonance (NMR)-Based Metabolomics.
Nuclear Magnetic Resonance (NMR)-Based Metabolomics.
Nuclear Magnetic Resonance (NMR)-Based Metabolomics.
Methods Mol Biol. 2011;708:321-34
Authors: Keun HC, Athersuch TJ
Biofluids are by far the most commonly studied sample type in metabolic profiling studies, encompassing blood, urine, cerebrospinal fluid, cell culture media and many others. A number of these fluids can be obtained at a high sampling frequency with minimal invasion, permitting detailed characterisation of dynamic metabolic events. One of the attractive properties of...
(1)H NMR-based metabolomics analysis of adult zebrafish (Danio rerio) after exposure to diniconazole as well as its bioaccumulation behavior.
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