[ASAP] Spontaneous Fluctuations Can Guide Drug Design Strategies for Structurally Disordered Proteins
Spontaneous Fluctuations Can Guide Drug Design Strategies for Structurally Disordered Proteins
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00504/20180705/images/medium/bi-2018-00504b_0004.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00504
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07-06-2018 09:40 AM
[ASAP] How Do Intrinsically Disordered Viral Proteins Hijack the Cell?
How Do Intrinsically Disordered Viral Proteins Hijack the Cell?
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00622/20180627/images/medium/bi-2018-00622j_0003.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00622
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06-29-2018 08:31 AM
[ASAP] Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins
Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00056/20180423/images/medium/bi-2018-00056k_0005.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00056
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04-24-2018 01:29 PM
New Structure of Key Protein Holds Clues for Better Drug Design - Drug Discovery & Development
New Structure of Key Protein Holds Clues for Better Drug Design - Drug Discovery & Development
http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcT1kdPCywa7_Peq_DtD9fXkY5_dRiMlMMPRdla0PAYYKE305o8lGDypaVvzHU62rj3Xid-pncET
Drug Discovery & Development
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New Structure of Key Protein Holds Clues for Better Drug Design
Drug Discovery & Development
To solve this problem, the researchers used a technique called nuclear magnetic resonance (NMR) spectroscopy, which creates strong magnetic fields to locate the positions of probes in a sample. Wüthrich is a...
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01-29-2018 01:57 PM
[NMR paper] NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins.
NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins.
NMR probing and visualization of correlated structural fluctuations in intrinsically disordered proteins.
Phys Chem Chem Phys. 2017 Apr 11;:
Authors: Kurzbach D, Beier A, Vanas A, Flamm AG, Platzer G, Schwarz TC, Konrat R
Abstract
A novel statistical analysis of paramagnetic relaxation enhancement (PRE) and paramagnetic relaxation interference (PRI) based nuclear magnetic resonance (NMR) data is proposed based on the...
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04-12-2017 10:57 AM
[NMR paper] Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness.
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness.
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness.
Chem Biol Drug Des. 2016 Jun 22;
Authors: Stefanachi A, Mangiatordi GF, Tardia P, Alberga D, Leonetti F, Niso M, Colabufo NA, Adamo C, Nicolotti O, Cellamare S
Abstract
...
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06-23-2016 10:34 AM
[NMR paper] NMR Screening in Fragment-Based Drug Design: A Practical Guide.
NMR Screening in Fragment-Based Drug Design: A Practical Guide.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR Screening in Fragment-Based Drug Design: A Practical Guide.
Methods Mol Biol. 2015;1263:197-208
Authors: Kim HY, Wyss DF
Abstract
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01-28-2015 03:22 AM
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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New Protein Evolution Insight Could Improve Drug Design
Drug Discovery & Development
The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ...
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New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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