[NMR paper] Magic angle spinning NMR of G protein-coupled receptors
Magic angle spinning NMR of G protein-coupled receptors
G protein-coupled receptors (GPCRs) have a simple seven transmembrane helix architecture which has evolved to recognize a diverse number of chemical signals. The more than 800 GPCRs encoded in the human genome function as receptors for vision, smell and taste, and mediate key physiological processes. Consequently, these receptors are a major target for pharmaceuticals. Protein crystallography and electron cryo-microscopy have provided high resolution structures of many GPCRs in both active and...
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03-18-2022 12:01 AM
[NMR paper] Universality of Sodium Ion Binding Mechanism in Class A G-Protein-Coupled Receptors
Universality of Sodium Ion Binding Mechanism in Class A G-Protein-Coupled Receptors
The allosteric modulation of GPCRs by sodium (Na+) ions has drawn significant attention due to the availability of crystal structures of several receptors showing Na+ ions bound to the inactive conformations at the conserved Asp2.50. To date, structures from 24 families of GPCRs have been determined, though mechanistic insights into Na+ binding to the allosteric site are limited. We performed 100's of ?s long simulations of 15 GPCRs and elucidated their Na+ binding mechanism. In class A GPCRs, Na+ ion...
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02-06-2018 07:42 PM
When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation
When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00845/20171016/images/medium/bi-2017-00845a_0003.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00845
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/4Eup-rPKLl8
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10-17-2017 10:19 AM
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
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Global G-Protein Coupled Receptors (GPCRs) Industry
Sacramento Bee
NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures II-4 ... G-PROTEIN COUPLED RECEPTORS (GPCR) - A CONCEPTUAL OVERVIEW II-7GPCR: Gateways to Cell II-7Classification of GPCRs II-7Table 1: List of Identified Known and Orphan (Non-Sensory)GPCRs ...
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08-15-2012 08:54 AM
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
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Global G-Protein Coupled Receptors (GPCRs) Industry
Sacramento Bee
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in ... NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures II-4 ...
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06-13-2012 11:34 AM
Structure and function of G protein-coupled receptors using NMR spectroscopy
Structure and function of G protein-coupled receptors using NMR spectroscopy
Publication year: 2010
Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 57, Issue 2</br>
Joseph A. Goncalves, Shivani Ahuja, Sina Erfani, Markus Eilers, Steven O. Smith</br>
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03-09-2012 09:16 AM
[NMR paper] Peptide hormone binding to G-protein-coupled receptors: structural characterization v
Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.
Related Articles Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.
Med Res Rev. 2001 Sep;21(5):450-71
Authors: Mierke DF, Giragossian C
G-protein-coupled receptors (GPCRs) allow cells to respond to calcium, hormones, and neurotransmitters. Not surprisingly, they currently make up the largest family of validated drug targets. Rational drug design for molecular regulators targeting GPCRs...
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11-19-2010 08:44 PM
Structure and function of G protein-coupled receptors using NMR spectroscopy
Structure and function of G protein-coupled receptors using NMR spectroscopy
Publication year: 2010
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 12 May 2010</br>
Joseph A., Goncalves , Shivani, Ahuja , Sina, Erfani , Markus, Eilers , Steven O., Smith</br>
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