[NMR paper] DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
Related Articles DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe.
Nat Commun. 2020 Sep 25;11(1):4857
Authors: Liu Q, He QT, Lyu X, Yang F, Zhu ZL, Xiao P, Yang Z, Zhang F, Yang ZY, Wang XY, Sun P, Wang QW, Qu CX, Gong Z, Lin JY, Xu Z, Song SL, Huang SM, Guo SC, Han MJ, Zhu KK, Chen X, Kahsai AW, Xiao KH, Kong W, Li FH, Ruan...
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09-28-2020 09:16 PM
[NMR paper] Trimethylsilyl tag for probing protein-ligand interactions by NMR.
Trimethylsilyl tag for probing protein-ligand interactions by NMR.
Trimethylsilyl tag for probing protein-ligand interactions by NMR.
J Biomol NMR. 2018 Mar 21;:
Authors: Becker W, Adams LA, Graham B, Wagner GE, Zangger K, Otting G, Nitsche C
Abstract
Protein-ligand titrations can readily be monitored with a trimethylsilyl (TMS) tag. Owing to the intensity, narrow line shape and unique chemical shift of a TMS group, dissociation constants can be determined from straightforward 1D 1H-NMR spectra not only in the fast but also in...
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03-23-2018 11:18 AM
Trimethylsilyl tag for probing proteinâ??ligand interactions by NMR
Trimethylsilyl tag for probing proteinâ??ligand interactions by NMR
Abstract
Proteinâ??ligand titrations can readily be monitored with a trimethylsilyl (TMS) tag. Owing to the intensity, narrow line shape and unique chemical shift of a TMS group, dissociation constants can be determined from straightforward 1D 1H-NMR spectra not only in the fast but also in the slow exchange limit. The tag is easily attached to cysteine residues and a sensitive reporter of ligand binding also at sites where it does not interfere with ligand binding or catalytic...
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03-21-2018 04:04 PM
Targeting Protein-Protein Interactions - Genetic Engineering News
Targeting Protein-Protein Interactions - Genetic Engineering News
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Targeting Protein-Protein Interactions
Genetic Engineering News
Researchers are scheduled to present the cutting edge of their tools and technologies targeting protein-protein interactions (PPIs) at Select Biosciences' upcoming â??Discovery Chemistry Congressâ?? meeting. New tools and approaches aimed at visualization ...
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02-15-2013 05:21 PM
[NMR paper] NMR studies of protein-ligand interactions.
NMR studies of protein-ligand interactions.
Related Articles NMR studies of protein-ligand interactions.
Methods Mol Biol. 2005;305:197-214
Authors: Maurer T
Interaction between biological macromolecules or of macromolecules with low-molecular-weight ligands is a central paradigm in the understanding of function in biological systems. It is also the major goal in pharmaceutical research to find and optimize ligands that modulate the function of biological macromolecules. Both technological advances and new methods in the field of nuclear...
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11-24-2010 11:14 PM
[NMR paper] Studies of protein-ligand interactions by NMR.
Studies of protein-ligand interactions by NMR.
Related Articles Studies of protein-ligand interactions by NMR.
Biochem Soc Trans. 2003 Oct;31(Pt 5):1006-9
Authors: Clarkson J, Campbell ID
Solution-state NMR has become an accepted method for studying the structure of small proteins in solution. This has resulted in over 3000 NMR-based co-ordinate sets being deposited in the Protein Databank. It is becoming increasingly apparent, however, that NMR is also a very powerful tool for accessing interactions between macromolecules and various ligands....
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11-24-2010 09:16 PM
[NMR paper] Studies of protein-ligand interactions by NMR.
Studies of protein-ligand interactions by NMR.
Related Articles Studies of protein-ligand interactions by NMR.
Methods Mol Biol. 1997;60:195-232
Authors: Craik DJ, Wilce JA
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08-22-2010 03:31 PM
[NMR paper] Studies of protein-ligand interactions by NMR.
Studies of protein-ligand interactions by NMR.
Related Articles Studies of protein-ligand interactions by NMR.
Methods Mol Biol. 1997;60:195-232
Authors: Craik DJ, Wilce JA