Research Chemist, Drug Optimization - Broad Institute, Cambridge, Massachusetts

[steveUK]

There's an interesting job on ScienceJobs ( scjobs.sciencemag.org ) that I thought I'd share:

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Job Title: Research Chemist I
Employer: Broad Institute
Job Location: Cambridge, Massachusetts, United States

The Broad Institute of MIT and Harvard seeks a RESEARCH CHEMIST I, Broad Institute-Infectious Disease Initiative, to work toward the design and optimization of biologically relevant small molecules for the chemical biology drug discovery program. Will employ state-of-the-art synthetic organic chemical techniques to generate focused series of small molecules for SAR exploration and in vivo testing. From the hits generated, will take part in follow-up synthetic activities aimed at increasing the affinity of the compounds to the biological target as well as optimization of pharmacological properties as necessary to advance chemical lead series towards clinical candidates. A robust suite of analytical techniques including 1D and 2D NMR, reverse and normal phase HPLC, SFC, and LC-MS will be invoked to evaluate both the structure and purity of compounds generated.

REQUIREMENTS: a Ph.D. in chemistry; one to two years of directly related experience; solid knowledge of analytical methods (NMR, LC/MS, IR); scientific expertise in analytical, synthetic, and organic chemistry, including various methods of purification and solid phase organic synthesis; proficiency in computational chemistry; and knowledge of other scientific disciplines and their integration with chemistry. Experience in solid phase organic synthesis a plus, as is knowledge of medicinal chemistry. Project management experience preferred. Must possess excellent communication skills and the ability to interact professionally with all levels of internal staff and with external contacts in a fast-paced environment. Excellent organization and time management skills required.

Interested applicants may apply online at www.broad.mit.edu/info/careers and reference job number MIT-00005269. Please indicate that you located this position on Sciencecareers.org. EOE.

PROFILE: the Broad Institute was founded to empower scientists of all kinds to work together on difficult, diverse, critical genomic and biomedical challenges. The Institute is a unique collaboration between the MIT and Harvard academic and medical communities, and it offers comprehensive benefits including:

* Competitive pay
* Medical, dental, life insurance plans
* 401(k) plan with matching contributions
* Tuition assistance plan
* Four weeks of vacation after one year
* T-Pass subsidy program

Join a team that works the way you've always wanted to work.

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http://scjobs.sciencemag.org/jobs/?job=28502