Postdoctoral position at Vanderbilt in Structural Biology of DNA Repair

[Omid]

Vanderbilt University's Center for Structural Biology are looking for a postdoc to study the structures of DNA repair machinery (found at http://www.icmrbs2008.org )

Post-Doctoral Position Available

A postdoctoral position is available as part of the large multi-investigator Structural Biology of DNA Repair Machinery (SBDR) program. SBDR is funded by the National Cancer Institute and supports multi-institutional teams of investigators at more than 10 universities across the US and one in the Netherlands. Our laboratory is the sole NMR lab in the SBDR and has both lab-centered and collaborative projects with SBDR and other investigators. Many projects involve the eukaryotic ssDNA binding protein, replication protein A (RPA), which is a 116 kDa heterotrimer containing 8 structural/functional domains. NMR is used to map binding sites between domains of RPA and other DNA replication and repair proteins such as DNA primase, SV40 large T antigen, ATRIP, Rad9, Mre11, and others. These studies are fully integrated with functional studies in vitro and in vivo. As part of the effort to understand the action of DNA replication and repair machinery, NMR, modeling and SAXS are used to characterize the dynamic architecture of full-length RPA and the remodeling of its architecture as the protein binds ssDNA and other proteins. Interested candidates should send a cover letter and CV to: walter.chazin@vanderbilt.edu.

http://structbio.vanderbilt.edu/chazin/position.html