Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York

		BioNMR > NMR career > Job marketplace
Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rating:

Display Modes

08-21-2010, 05:17 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,697

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York

Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York

A postdoctoral position to study the solution dynamics and structure
of protein kinases is available on a NIH funded project (REF#:
HS-R-6453-10-08-S). Our group is interested in how static and dynamic
changes of protein structure affect the activity of protein kinases.
We combine X-ray crystallography, NMR and ligand binding kinetics with
collaborative molecular dynamic studies (See e.g. ref 1 and 2). Our
research group is located at Stony Brook University in a highly
interactive environment with the New York Structural Biology Center
and Brookhaven National Laboratory. Varian and Bruker NMR instruments
with 500-700 MHz field strenghts are available on site. As a member of
the New York Structural Biology Center, we have access to 800 MHz and
900 MHz instruments as well as a access to a large pool of NMR
expertise. The location of Stony Brook University within public
transport commuting distance to New York City and the north shore of
Long Island provide a convenient work-life balance and a family
friendly environment.
Interested candidates with a strong background in protein NMR should
email their CV and the names of three references to Markus Seeliger
(markus.seeliger@gmail.com).

1.) Shan, Y., Seeliger, M.A., et al. A conserved
protonation-dependent switch controls drug binding in the Abl kinase.
Proc Natl Acad Sci U S A, 2009. 106(1): p. 139-44.

2.) Seeliger, M.A., et al., Equally potent inhibition of c-Src and Abl
by compounds that recognize inactive kinase conformations. Cancer Res,
2009. 69(6): p. 2384-92.

************************************************** *****
Markus Seelige
Assistant Professor
Department of Pharmacological Sciences
Stony Brook University Medical School, BST 7-125
Stony Brook, NY 11794-8651
phone: (631) 444-3558 fax: (631) 444-9749
http://www.pharm.stonybrook.edu/seeliger
************************************************** *****

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Structure determination in "shiftless" solid state NMR of oriented protein samples. Structure determination in "shiftless" solid state NMR of oriented protein samples. Structure determination in "shiftless" solid state NMR of oriented protein samples. J Magn Reson. 2011 Jul 6; Authors: Yin Y, Nevzorov AA An efficient formalism for calculating protein structures from oriented-sample NMR data in the torsion-angle space is presented. Angular anisotropies of the NMR observables are treated by utilizing an irreducible spherical basis of rotations. An intermediate rotational transformation is introduced that greatly speeds up...	nmrlearner	Journal club	0	07-12-2011 06:23 PM
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States The New York Structural Biology Center (NYSBC) seeks an experienced electron microscopist to join the staff of its Cryo-Electron Microscope Facility (http://cryoem.nysbc.org). The NYSBC is shared center that supports state-of-the-art research in cryo-EM, NMR, and X-ray. Cryo-EM facilities include four transmission electron microscopes and a new d... More...	nmrlearner	Job marketplace	0	01-26-2011 04:21 AM
[NMR tweet] How is "Tyrannosaurus" related to "Nuclear Magnetic Resonance"? http://www.threewiki.com/60YeHE @threewiki How is "Tyrannosaurus" related to "Nuclear Magnetic Resonance"? http://www.threewiki.com/60YeHE @threewiki Published by Jakob7 (Jakob Baumhardt) on 2010-12-04T05:24:13Z Source: Twitter	nmrlearner	Twitter NMR	0	12-04-2010 05:30 AM
Postdoctoral position New York Postdoctoral position New York Postdoctoral position: Experimental, numerical and/or theoretical studies of spin diffusion Brooklyn College, City University of New York, New York, USA Inquiries are invited for a postdoctoral research position at the City University of New York, New York. Our immediate interest is in studying spin-diffusion, starting from small aggregates, theoretically	nmrlearner	Job marketplace	0	12-01-2010 08:36 PM
[NMR paper] Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments. Related Articles Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments. J Am Chem Soc. 2002 Oct 16;124(41):12352-60 Authors: Skrynnikov NR, Dahlquist FW, Kay LE Carr-Purcell-Meiboom-Gill (CPMG) relaxation measurements employing trains of 180 degrees pulses with variable pulse spacing provide valuable information about systems undergoing millisecond-time-scale chemical exchange. Fits of the CPMG relaxation...	nmrlearner	Journal club	0	11-24-2010 08:58 PM
[NMR paper] Lanthanide ions bind specifically to an added "EF-hand" and orient a membrane protein Lanthanide ions bind specifically to an added "EF-hand" and orient a membrane protein in micelles for solution NMR spectroscopy. Related Articles Lanthanide ions bind specifically to an added "EF-hand" and orient a membrane protein in micelles for solution NMR spectroscopy. J Magn Reson. 2000 Oct;146(2):381-4 Authors: Ma C, Opella SJ Twelve amino acid residues corresponding to an "EF-hand" calcium-binding site were added to the N-terminus of a protein, providing a specific lanthanide ion binding that weakly orients the protein in solution. A...	nmrlearner	Journal club	0	11-19-2010 08:29 PM
Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York Postdoctoral Position "Solution Dynamics of Protein Kinases" in New York A postdoctoral position to study the solution dynamics and structure of protein kinases is available on a NIH funded project (REF#: HS-R-6453-10-08-S). Our group is interested in how static and dynamic changes of protein structure affect the activity of protein kinases. We combine X-ray crystallography, NMR and ligand binding kinetics with collaborative molecular dynamic studies (See e.g. ref 1 and 2). Our research group is located at Stony Brook University in a highly interactive environment with the New York...	nmrlearner	Job marketplace	0	08-21-2010 05:14 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off