Postdoctoral Position in NMR and molecular modeling at Paris Descartes University

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Postdoctoral Position in NMR and molecular modeling at Paris Descartes University

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NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

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12-01-2010, 08:36 PM

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Postdoctoral Position in NMR and molecular modeling at Paris Descartes University

Postdoctoral Position in NMR and molecular modeling at Paris Descartes University

Paris Descartes University
UMR8601 CNRS

12 months post-doctoral position in Structural Biology NMR.

The postdoctoral position is available from February 2011 in the Paris Descartes University to characterize the interaction of new anti-cancer inhibitors with phosphorylated peptide-betaTrCP complex.

Applicants should have a Ph.D. in Biochemistry, Chemistry or related fields.

The candidate is expected to have a strong expertise in solution NMR with in-depth training in NMR receptor-ligand interaction, protein structures and dynamics, and drug-protein interactions. Familiarity with biochemistry, biophysics, and molecular biology is desirable.
Experience with molecular modelling (docking, virtual screening) and python language will be a big plus.

The candidate will join our NMR & Molecular modeling team of the laboratory of Chemical and Biochemical Pharmacology and Toxicology (UMR8601 CNRS), and be responsible for the development and structural analysis of anti-cancer by high-resolution solution NMR and molecular modeling. The main approach will be to characterize the interaction by transfer-NMR experiments (STD, WaterLOGSY, ...) and to participate in the development of AuPosSOM software (www.aupossom.com) to classify molecules according to their contact pattern with the target of interest and 2D/3D QSAR modeling.

Funding for the position is provided by the French National Agency of Research (ANR) for 1 year.

For any queries about the lab and research projects, please contact Nathalie Evrard-Todeschi by e-mail:
Nathalie.Evrard-Todeschi@parisdescartes.fr

--

Dr Gildas BERTHO
Université Paris Descartes
UMR 8601 CNRS
Équipe de RMN et Modélisation Moléculaire
45 rue des Saints-Pères
75006 Paris, FRANCE
Tel : +33-(0)1-42-86-21-82
Fax : +33-(0)1-42-86-40-50
Email : gildas.bertho@parisdescartes.fr[...s.blogspot.com[/IMG]

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