Postdocs, Students, Technician in RNA-protein NMR at CEITEC (Brno/CZ)

[peter.lukavsky]

Dear colleagues, the Lukavsky Lab has openings for two postdocs, students and one technician at CEITEC (Brno/CZ) to work on RNA-based regulation of gene expression. We are focused on understanding molecular principles of RNA-protein assemblies regulating gene expression at the posttranscriptional level. In the cytoplasm, gene expression is timely and spatially coordinated to ensure that proteins are produced at the right place and time in the cell. Failure to properly transport and localize mRNAs and to control protein expression can lead to impairment of memory formation, neurobiological diseases and cancer.
We plan to study regulatory RNA elements found in neuronal mRNAs important for learning, memory formation and neurobiological diseases and their interaction with protein partners. We put a strong focus on alternative splicing, mRNA transport and translational control.
Our main structural tool is NMR spectroscopy, which we have successfully applied to determine several structures of large, regulatory RNAs and complexes. Our structural work is always accompanied by biochemical and functional studies to gain profound insights how regulatory RNAs and their complexes function in the cell.
CEITEC is a vibrant work place, with excellent colleagues and infrastructure for structural biology including six high-field NMR instruments from 500 to 950 MHz equipped with cryo-probes.

Successful candidates should be highly motivated and creative and share our fascination for RNA structure and function. Previous experience in molecular biology, biophysics and biochemistry are a plus. Good communication and interpersonal skills and fluency in spoken and written English are required.

For contact: peter.lukavsky@ceitec.muni.cz