Postdoc - BioNMR

		BioNMR > NMR career > Job marketplace
Postdoc

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

01-11-2012, 04:10 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,734

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Postdoc

Postdoc

A postdoc position on protein-ligand interactions and fragment-based drug design by NMR is available at the Helmholtz Zentrum München

http://www.helmholtz-muenchen.de/fil...hp?id=1243&L=1

Job Details

The candidate will be responsible for characterizing protein-ligand interactions and implementing fragment-based approaches by NMR spectroscopy for the identification and optimization of small molecule inhibitors targeting disease-linked pathways. The scientist will be working in the group of Michael Sattler at the Institute of Structural Biology (http://www.helmholtz-muenchen.de/stb) in close collaboration with structural biologists using NMR-spectroscopy and X-ray crystallography for studying protein-ligand interactions. Interactions are expected with the Protein Expression and Purification Facility and the Assay Development and Screening Facility. The scientist should establish NMR-monitored fragment-based screening and support on-going projects in the identification and optimization of small molecule hits and leads using structural biology (NMR and X-ray crystallography). Tasks include:

- Implementing a fragment library and NMR-monitored screening
- Application of NMR based methods for protein-ligand interactions (ligand and target based)
- Hit validation and structural analysis of protein-ligand complexes by NMR and/or X-ray crystallography
- Implementation and development of new methods and techniques
- Interaction and project-driven collaborations with biologists and chemists, e.g. for establishing structure-activity relationships

The candidate is expected to interact and collaborate with researchers at HMGU.

Qualifications

- Doctoral degree in Chemistry, Biochemistry, Life Sciences, Physics, or related
- Demonstrated strong experience with structural biology and/or structure-based techniques for studying protein-ligand complexes
- Experience with training and supervision of students is desired
- We expect high motivation, creativity and a strong commitment to team work.
- Strong communication and organizational skills are expected
- Previous experience with chemical compound libraries is desirable

Our Offer

- Research scientist in the Institute of Structural Biology at the Helmholtz Zentrum München
- Supporting innovative research on important biological pathways linked to human disease.
- Working in a vibrating and scientifically stimulating environment with excellent facilities for NMR (http://www.bnmrz.org), structural biology, protein biochemistry, cell biology, imaging, animal models, and more.
- Opportunities and support in management skills

For further information please contact Michael Sattler (sattler@helmholtz-muenchen.de)

The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.

Applications should be addressed to Waltraud Wolfson (waltraud.wolfson@helmholtz-muenchen.de)

Helmholtz Zentrum München
German Research Center for Environmental Health (GmbH)
Ingolstädter Landstr. 1
85764 Neuherberg
Germany

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Postdoc Postdoc An opening exists at the University of Georgia for a postdoctoral associate to work on structural characterization of proteins using advanced NMR techniques. Primary responsibilities reside with our role in the Northeast Structural Genomics Consortium (NESG). These responsibilities involve structure improvement and validation of structures using RDC and RCSA data, as well as the production of a number of biologically relevant protein structures. Our lab also has strong programs in the glycobiology and vesicle trafficking areas, and we anticipate opportunities to be involved...	nmrlearner	Job marketplace	0	01-11-2012 04:10 PM
Postdoc Postdoc Post-Doc Position at CEA-Saclay (Paris) in NMR / MRI instrumentation A one-year post-doctoral position is available to join the group of Dr. Dimitris Sakellariou at the Laboratory of Structure and Dynamics by Magnetic Resonance at the French Alternative Energies and Atomic Energy Commission of Saclay in Paris. Our focus is primarily directed at developing a novel instrumentation for in vivo Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) of complex matter and small animals. The project is funded by the European Research Council for the next two years. The duration...	nmrlearner	Job marketplace	0	01-11-2012 04:10 PM
Postdoc Postdoc In connection with a collaboration agreement with Janssen Pharmaceutica, Beerse, Belgium, the University of Liege has a postdoctoral vacancy available. We are looking for a highly motivated individual with a sound understanding of ssNMR theory and extensive experience in implementing, setting up, running, processing and evaluating ssNMR experiments, preferably in the context of pharmaceutical applications. The successful candidate will be responsible for setting-up a ssNMR research environment suitable for pharmaceutical	nmrlearner	Job marketplace	0	01-11-2012 04:10 PM
Postdoc Postdoc A two-year post-doc position is available in the field of Solid State NMR At: Nano-SiSTeMI Interdisciplinary Centre, University of Piemonte Orientale Where: Alessandria, Italy; Milan, Italy Task: The aim of the project, in collaboration with Bruker (Italy) is to develop,	nmrlearner	Job marketplace	0	01-11-2012 04:10 PM
Postdoc Postdoc Structural studies of Vpx, the accessory protein of the HIV-2 We are looking for a candidate to apply for a 2 years postdoctoral position in the Laboratory of Biological NMR and Crystallography at the University Paris Descartes. The project will aim to determine the structure of the Vpx protein (112 amino acids) and of its complexes with inhibitors identified after screening of small compound libraries, using high-field multidimensional NMR and Molecular Modeling. HIV-2 is the second leading cause of AIDS in humans and	nmrlearner	Job marketplace	0	07-20-2011 10:24 PM
PhD (6) - Postdoc (5) PhD (6) - Postdoc (5) Large investment in UltraSense NMR for Analyses, screening and diagnostics. UltraSense NMR is a large research and development programme, granted by EFRO(EU) and GO, in cooperation between science and business. The project will be run by a consortium between Radboud University Nijmegen: Institute of Molecules and Materials, UMC St. Radboud, University of Twente and 3 knowledge companies: Future Chemistry, Spinnovation Analytical and NovioGendix. Goal of the project is to develop hyperpolarisation equipment and strategies based on both physical (DNP) and chemical...	nmrlearner	Job marketplace	0	04-07-2011 11:40 PM
Postdoc Postdoc Umeå University - with its 33,500 students and over 4,200 employees - is an organisation in constant change and development. Umeå University conducts groundbreaking research within several areas - several in which we are among the best in the world - within others regarded as the leaders in Sweden. We are one of Sweden’s largest providers of education and offer a broad and attractive range of courses and programmes. Our campus constitutes an inspiring environment for everyone that studies and works here. We wish to co-operate with companies and organisations throughout the Umeå...	nmrlearner	Job marketplace	0	01-26-2011 04:27 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off