A position is available at the Université de Lyon (France). The selected candidate will join Isabelle KRIMM's team as a post-doc for two years and will work on a project funded by the National Agency for Research (ANR). The general framework of the project is the study of protein-ligand interactions and fragment-based drug design by NMR. The candidate will be involved in NMR experiments and/or modelisation and/or programming.
[Question from NMRWiki Q&A forum] protein-ligand interactions 2D NMR
protein-ligand interactions 2D NMR
I want to judge ligand protein interactions. Mine one is a dimer protein. Other than HSQC perturbation which other 2DNMR experiments useful to know the interaction?
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05-18-2011 08:51 PM
NMR Applications for Identifying ?-TrCP Protein-Ligand Interactions.
NMR Applications for Identifying ?-TrCP Protein-Ligand Interactions.
NMR Applications for Identifying ?-TrCP Protein-Ligand Interactions.
Mini Rev Med Chem. 2011 Jan 11;
Authors: Pons J, Tanchou V, Girault JP, Bertho G, Evrard-Todeschi N
Without crystallographic data, NMR has emerged as the best way to define protein-ligand interactions. Using NMR experiments based on magnetization transfer, one can select molecules bound, estimate the dissociation constant, identify contacts implied in the binding, obtain a structure of the bound ligand and make...
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01-13-2011 12:00 PM
[NMR paper] Probing the binding entropy of ligand-protein interactions by NMR.
Probing the binding entropy of ligand-protein interactions by NMR.
Related Articles Probing the binding entropy of ligand-protein interactions by NMR.
Chembiochem. 2005 Sep;6(9):1585-91
Authors: Homans SW
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12-01-2010 06:56 PM
[NMR paper] NMR studies of protein-ligand interactions.
NMR studies of protein-ligand interactions.
Related Articles NMR studies of protein-ligand interactions.
Methods Mol Biol. 2005;305:197-214
Authors: Maurer T
Interaction between biological macromolecules or of macromolecules with low-molecular-weight ligands is a central paradigm in the understanding of function in biological systems. It is also the major goal in pharmaceutical research to find and optimize ligands that modulate the function of biological macromolecules. Both technological advances and new methods in the field of nuclear...
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11-24-2010 11:14 PM
[NMR paper] Studies of protein-ligand interactions by NMR.
Studies of protein-ligand interactions by NMR.
Related Articles Studies of protein-ligand interactions by NMR.
Biochem Soc Trans. 2003 Oct;31(Pt 5):1006-9
Authors: Clarkson J, Campbell ID
Solution-state NMR has become an accepted method for studying the structure of small proteins in solution. This has resulted in over 3000 NMR-based co-ordinate sets being deposited in the Protein Databank. It is becoming increasingly apparent, however, that NMR is also a very powerful tool for accessing interactions between macromolecules and various ligands....
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11-24-2010 09:16 PM
[NMR paper] Studies of protein-ligand interactions by NMR.
Studies of protein-ligand interactions by NMR.
Related Articles Studies of protein-ligand interactions by NMR.
Methods Mol Biol. 1997;60:195-232
Authors: Craik DJ, Wilce JA
nmrlearner
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08-22-2010 03:31 PM
[NMR paper] Studies of protein-ligand interactions by NMR.
Studies of protein-ligand interactions by NMR.
Related Articles Studies of protein-ligand interactions by NMR.
Methods Mol Biol. 1997;60:195-232
Authors: Craik DJ, Wilce JA
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08-22-2010 03:03 PM
[NMR paper] On the ligand-protein and ligand-flavin interactions in NADPH-adrenodoxin reductase a
On the ligand-protein and ligand-flavin interactions in NADPH-adrenodoxin reductase as studied by 31P- and 13C-NMR. Use of 13C-enriched FAD as a probe.
Related Articles On the ligand-protein and ligand-flavin interactions in NADPH-adrenodoxin reductase as studied by 31P- and 13C-NMR. Use of 13C-enriched FAD as a probe.
J Biochem. 1991 Jan;109(1):144-9
Authors: Fujii S, Nonaka Y, Okamoto M, Miura R
The interaction between 2',5'-ADP and NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria was examined by titrating the enzyme with...
Post-doc position: *protein-ligand interactions/FBDD*
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