Macromolecular NMR Spectroscopist

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Macromolecular NMR Spectroscopist

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NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

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08-21-2010, 05:17 AM

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Macromolecular NMR Spectroscopist

Macromolecular NMR Spectroscopist

The Structural Biophysics Laboratory, National Cancer Institute is seeking the support of a Macromolecular NMR spectroscopist who will work with and support the PIs in the Structural Biophysics Laboratory (SBL) For info on the SBL visit: [ http://go.cancer.gov/sbljobs]. The position will be hired by the SAIC-Frederick and dedicated to the SBL.

The Scientist II will work with and support principal investigators in the Structural Biophysics Laboratory (SBL) in the determination of biological macromolecular structures using high-field NMR (500-850 MHz Varian and /or Bruker systems). The Scientist II will also work with an NMR engineer to trouble shoot and resolve instrumental issues. The duties in this position include, but are not limited to: Training and assisting users in operation of sophisticated multi-dimensional macromolecular NMR experiments; Maintenance and development of experimental protocols (either as implementation of published methods or development of new methods, with opportunity to collaborate with scientists within the SBL); General instrument oversight, including scheduling and supervision of cryogen and magnet maintenance; and Cooperation with an on-site NMR engineer for trouble shooting and problem resolution. This position is located in Frederick, Maryland.

REQUIRED SKILLS: Possession of Doctoral degree from an accredited college or university appropriate to biomedical research, or eight (8) years related experience in lieu of degree. Doctoral degree with postdoctoral experience in macromolecular nuclear magnetic resonance (NMR) is preferred. In addition to educational requirements, two (2) years of post doctoral education experience in NMR maintenance and application. Experience and expertise with current Varian and Bruker systems/software is essential. The ability to work in a highly interactive setting with a number of different investigators is critical.

DESIRED SKILLS: Background and expertise in the development and application of multi-dimensional biological NMR spectroscopy, both in the determination of protein and DNA structures. Proficiency in NMR engineering is also desirable. The ability to prepare and submit scientific manuscripts is highly desirable.

Interested applicants should visit the SAIC-Frederick website for more information.
https://cp-its-rmprd.saic.com/MAIN/careerportal/ and search for Job Posting No. 177172.

Attendees at the 2010 EUROMAR may contact R. Andrew Byrd for discussions of this position.

===============================================
R. Andrew Byrd 301-846-1407
Dir., Molecular Discovery Program
Chief, Structural Biophysics Laboratory FAX 301-846-6231
Macromolecular NMR byrdra@mail.nih.gov
http://ccr.cancer.gov/resources/sbl/

Center for Cancer Research
National Cancer Institute-Frederick
P.O. Box B, Bldg. 538
Frederick, MD 21702-1201
===============================================

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