CHN - Chengdu, PhDs in structural/computational chemistry with at least 3 yrs experience in computer-aided drug design. LI/LO and/or modern multi-nuclear NMR techniques in structure elucidation and NMR maintenan
Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping.
Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping.
Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping.
Chem Biol Drug Des. 2010 Sep 1;76(3):218-33
Authors: Begley DW, Zheng S, Varani G
Solution-state nuclear magnetic resonance (NMR) is a versatile tool for the study of binding interactions between small molecules and macromolecular targets. We applied ligand-based NMR techniques to the study of human thymidylate synthase (hTS) using known...
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01-05-2011 09:51 PM
[NMR paper] Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, an
Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins.
Related Articles Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins.
Biochemistry. 2005 May 24;44(20):7414-26
Authors: Chen TS, Chung FY, Tjong SC, Goh KS, Huang WN, Chien KY, Wu PL, Lin HC, Chen CJ, Wu WG
Natural homologues of cobra cardiotoxins (CTXs) were...
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11-25-2010 08:21 PM
NMR Specialist - Pharmaceutical Chemistry - Cheshire - Kelly Scientific Resources - N
NMR Specialist - Pharmaceutical Chemistry - Cheshire - Kelly Scientific Resources - North West - Cheshire, England
NMR Specialist - Pharmaceutical Chemistry - Cheshire
My client is a global leader within pharmaceuticals, and there is currently an opportunity available within their R&D facility in the North West for an 11 month contract NMR scientist.
Supporting research within oncology chemistry, this role will provide expert...
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11-22-2010 07:08 PM
[NMR paper] NMR spectroscopy in drug discovery: tools for combinatorial chemistry, natural produc
NMR spectroscopy in drug discovery: tools for combinatorial chemistry, natural products, and metabolism research.
Related Articles NMR spectroscopy in drug discovery: tools for combinatorial chemistry, natural products, and metabolism research.
Prog Drug Res. 2000;55:137-211
Authors: Keifer PA
NMR spectroscopy has enjoyed many advances recently, and the pace of development shows no signs of slowing. This article focuses on advances that have affected solution-state NMR. These advances fall into three general categories: new experimental...
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11-18-2010 09:15 PM
Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery.
Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery.
Related Articles Application of NMR Spectroscopy in Medicinal Chemistry and Drug Discovery.
Curr Top Med Chem. 2010 Sep 2;
Authors: Ohno A, Inomata K, Tochio H, Shirakawa M
"In-cell nuclear magnetic resonance (NMR)" is a unique method for characterization of conformation, interaction and dynamics of proteins inside living cells at atomic level. Since the method was proposed by Dötch and co-workers in 2001 , its application had been limited to bacterial cells and...
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09-03-2010 02:30 PM
Postdoctoral Position in Molecular and Structural Biology, Chemistry Department, Univ
Postdoctoral Position in Molecular and Structural Biology, Chemistry Department, University of Calif - University of California Davis - Davis, CA, United States
A postdoctoral position in molecular and structural biology is available immediately to study structure-activity relationships (SAR by NMR) and drug design for the microbial protein FtsZ, an important target for antibiotics drugs. The goal of the study will be to clone and prepare functional fragments and mutants of FtsZ that will be used in NMR s...
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08-26-2010 04:54 AM
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