The enzyme PP1 plays a vital role in countless biochemical processes in the body and is the pivot around which many diseases turn. It is so ubiquitous that until now drug development has tended to avoid it because the side effects and complications that arise when it is targeted are too risky. Now, researchers at Brown University, have used NMR spectroscopy and X-ray crystallography to help them focus on how PP1 interacts with other proteins to understand specific behaviour that might nevertheless be...
[NMR paper] Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy.
Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy.
Related Articles Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy.
Biochem Biophys Res Commun. 2013 Dec 13;
Authors: Shin JS, Ha JH, Chi SW
Abstract
Inhibition of the interaction between the p53 tumor suppressor and its negative regulator MDM2 is of great importance to cancer therapy. The anti-apoptotic Bcl-2 family proteins are also attractive anti-cancer molecular...
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[NMR paper] Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching.
Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching.
Identification of fragments targeting an alternative pocket on HIV-1 gp41 by NMR screening and similarity searching.
Bioorg Med Chem Lett. 2013 Jul 22;
Authors: Chu S, Gochin M
Abstract
The HIV-1 envelope glycoprotein gp41 fusion intermediate is a promising drug target for inhibiting viral entry. However, drug development has been impeded by challenges inherent in mediating the underlying protein-protein interaction. Here...
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08-13-2013 04:26 PM
A Potentially Life-Saving Protein Takes Shape - Science Daily (press release)
A Potentially Life-Saving Protein Takes Shape - Science Daily (press release)
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A Potentially Life-Saving Protein Takes Shape
Science Daily (press release)
July 2, 2013 â?? A tiny protein called ubiquitin -- so named because it is present in every cell of living things as dissimilar as hollyhocks and humans -- may hold the key to treatment for a variety of diseases from Parkinson's to diabetes. The protein ...
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07-10-2013 04:12 AM
A Potentially Life - Saving Protein Takes Shape - Science Daily (press release)
A Potentially Life - Saving Protein Takes Shape - Science Daily (press release)
<img alt="" height="1" width="1" />
A Potentially Life - Saving Protein Takes Shape
Science Daily (press release)
July 2, 2013 â?? A tiny protein called ubiquitin -- so named because it is present in every cell of living things as dissimilar as hollyhocks and humans -- may hold the key to treatment for a variety of diseases from Parkinson's to diabetes. The protein ...
and more »
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07-02-2013 10:20 PM
Potentially life-saving protein takes shape: Ubiquitin's novel forms suggest ... - Phys.Org
Potentially life-saving protein takes shape: Ubiquitin's novel forms suggest ... - Phys.Org
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Potentially life-saving protein takes shape: Ubiquitin's novel forms suggest ...
Phys.Org
... protein takes shape: Ubiquitin's novel forms suggest novel functions. 46 minutes ago. A tiny protein called ubiquitin â?? so named because it is present in every cell of living things as dissimilar as hollyhocks and humans - may hold the key to ...
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[NMR paper] Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhib
Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.
Related Articles Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.
Bioorg Med Chem Lett. 2001 Jul 9;11(13):1665-9
Authors: Sundaramoorthi R, Siedem C, Vu CB, Dalgarno DC, Laird EC, Botfield MC, Combs AB, Adams SE, Yuan RW, Weigele M, Narula SS
Detailed analysis of Src SH2 binding by peptides containing a...
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11-19-2010 08:44 PM
[NMR paper] Synthesis and structure determination by NMR of a putative vacuolar targeting peptide
Synthesis and structure determination by NMR of a putative vacuolar targeting peptide and model of a proteinase inhibitor from Nicotiana alata.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-acspubs.jpg Related Articles Synthesis and structure determination by NMR of a putative vacuolar targeting peptide and model of a proteinase inhibitor from Nicotiana alata.
Biochemistry. 1996 Jan 16;35(2):369-78
Authors: Nielsen KJ, Hill JM, Anderson MA, Craik DJ
NA-proPI is a 40.3-kDa multidomain precursor protein found in the...
Targeting PP1: NMR takes aim
The enzyme PP1 plays a vital role in countless biochemical processes in the body and is the pivot around which many diseases turn. It is so ubiquitous that until now drug development has tended to avoid it because the side effects and complications that arise when it is targeted are too risky. Now, researchers at Brown University, have used NMR spectroscopy and X-ray crystallography to help them focus on how PP1 interacts with other proteins to understand specific behaviour that might nevertheless be...
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