A powerful new NMR technique DiffErential EPitope mapping by STD NMR spectroscopy (DEEP-STD NMR) is being used by researchers in the UK to reveal the nature of the contact between ligand and protein target with a view to developing new pharmaceuticals with fewer side-effects.
Completing the Drug Design Jigsaw - R & D Magazine
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R & D Magazine
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Completing the Drug Design Jigsaw
R & D Magazine
It adapts a technique known as ligand-based Nuclear Magnetic Resonance (NMR) spectroscopy to reveal which amino acids in the protein are involved in binding to the drug. They were able to do this by examining the drug and without having to label the ...
Completing the Drug Design Jigsaw - R & D Magazine
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10-06-2017 10:39 AM
Completing the drug design jigsaw - Phys.Org
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Phys.Org
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Completing the drug design jigsaw
Phys.Org
It adapts a technique known as ligand-based Nuclear Magnetic Resonance (NMR) spectroscopy to reveal which amino acids in the protein are involved in binding to the drug. They were able to do this by examining the drug and without having to label the ...
and more »
Completing the drug design jigsaw - Phys.Org
nmrlearner
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10-05-2017 07:28 PM
[NMR paper] NMR in drug design.
NMR in drug design.
Related Articles NMR in drug design.
Arch Biochem Biophys. 2017 Jun 12;:
Authors: Harner MJ, Mueller L, Robbins KJ, Reily MD
Abstract
The use of NMR as a tool to determine 3 dimensional protein solution structures, once a darling of the pharmaceutical industry, has largely given way to study of the interaction of prospective drugs with macromolecular targets. Many of these approaches involve ligand-centered studies, which have the advantage of speed and efficiency, but there are also many approaches that take...
nmrlearner
Journal club
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06-18-2017 12:12 PM
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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New Protein Evolution Insight Could Improve Drug Design
Drug Discovery & Development
The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ...
and more »
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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nmrlearner
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10-01-2013 09:43 AM
Structure-Based Drug Design
Structure-Based Drug Design
http://www.spectroscopynow.com/common/images/thumbnails/no_img.gifThe 13th Structure-Based Drug Discovery conference will feature the development of in silico technology as well as experimental approaches useful for accurately predicting and modeling the structures of proteins in structure-based drug design efforts.
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nmrlearner
Conferences
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05-22-2013 04:43 PM
[NMR paper] Application of difference NOE-pumping NMR technique and cold-spray ionization mass sp
Application of difference NOE-pumping NMR technique and cold-spray ionization mass spectrometry to identify a ligand binding with a protein receptor.
Related Articles Application of difference NOE-pumping NMR technique and cold-spray ionization mass spectrometry to identify a ligand binding with a protein receptor.
Anal Sci. 2004 Oct;20(10):1467-70
Authors: Seki H, Sei Y, Shikii K, Shimotakahara S, Utsumi H, Yamaguchi K, Tashiro M
A difference diffusion-based NMR technique and cold-spray ionization mass spectrometry were employed as a...
nmrlearner
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11-24-2010 10:01 PM
[BMNRC community] Perspectives on NMR in drug discovery: a technique comes of age
Perspectives on NMR in drug discovery: a technique comes of age
http://www.nature.com/nrd/journal/v7/n9/abs/nrd2606.html
Nature Reviews Drug Discovery 7, 738-745 (September 2008) | doi:10.1038/nrd2606
Go to BMNRC community to find more info about this topic.
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News from other NMR forums
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09-02-2010 04:59 AM
[NMR paper] NMR spectroscopy in structure-based drug design.
NMR spectroscopy in structure-based drug design.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR spectroscopy in structure-based drug design.
Curr Opin Biotechnol. 1999 Feb;10(1):42-7
Authors: Roberts GC
NMR methods for the study of motion in proteins continue to improve, and a number of studies of protein-ligand complexes relevant to drug design have been reported over the past year, for example, studies of fatty-acid-binding protein and SH2 and SH3 domains. These...
Spot the difference: NMR technique for drug design
A powerful new NMR technique DiffErential EPitope mapping by STD NMR spectroscopy (DEEP-STD NMR) is being used by researchers in the UK to reveal the nature of the contact between ligand and protein target with a view to developing new pharmaceuticals with fewer side-effects.
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