Drugs that are inhibitors of the protein sclerostin could be used to treat the debilitating bone-loss disease osteoporosis, according to researchers in Germany who used nuclear magnetic resonance (NMR) spectroscopy in thier investigations.
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in Check - Broadway World
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in Check - Broadway World
<img alt="" height="1" width="1" />
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in Check
Broadway World
In their studies, the researchers used a structural analysis technique called NMR spectroscopy to map the 3-D structure of p53 binding to BCL-xL. Their experiments also revealed in detail how one region of the p53 protein, called the DNA-binding domain ...
and more »
Read here
nmrlearner
Online News
0
05-26-2014 09:25 PM
Detailed Studies Reveal How Key Cancer-Fighting Protein Is Held in Check - Newswise (press release)
Detailed Studies Reveal How Key Cancer-Fighting Protein Is Held in Check - Newswise (press release)
<img alt="" height="1" width="1" />
Detailed Studies Reveal How Key Cancer-Fighting Protein Is Held in Check
Newswise (press release)
... Studies Reveal How Key Cancer-Fighting Protein Is Held in Check. St. Jude Children's Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to ...
Read here
nmrlearner
Online News
0
05-22-2014 01:48 AM
Detailed studies reveal how key cancer-fighting protein is held in check - HealthCanal.com
Detailed studies reveal how key cancer-fighting protein is held in check - HealthCanal.com
<img alt="" height="1" width="1" />
Detailed studies reveal how key cancer-fighting protein is held in check
HealthCanal.com
In their studies, the researchers used a structural analysis technique called NMR spectroscopy to map the 3-D structure of p53 binding to BCL-xL. Their experiments also revealed in detail how one region of the p53 protein, called the DNA-binding domain ...
and more »
Read here
nmrlearner
Online News
0
05-17-2014 01:15 PM
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in Check - Virtual-Strategy Magazine (press release)
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in Check - Virtual-Strategy Magazine (press release)
<img alt="" height="1" width="1" />
Detailed Studies Reveal how key Cancer-Fighting Protein is Held in Check
Virtual-Strategy Magazine (press release)
St. Jude Children's Research Hospital analysis reveals how the protein p53, which triggers cancer cells to commit suicide, attaches to its regulatory molecule; findings could lead to drugs to unleash p53 to battle a range of cancers. Memphis, Tenn ...
and more »
Read here
nmrlearner
Online News
0
05-15-2014 07:23 PM
[NMR software blog] Fighting the Pirate
Fighting the Pirate
Six years ago I took the decision of investing my efforts into the creation of a software application. It was a complex project that potentially required thousands of hours of work. I had to make it financially viable. No sponsor was in sight, so the only solution was to make a commercial program and sell it. I was extremely lucky, because the facilities to sell it were readily available and convenient too.
The difference between a normal application and a commercial one is that the latter must be copy-protected in some way.
I had complete freedom about how which...
nmrlearner
News from NMR blogs
0
04-11-2011 01:00 PM
[NMR paper] In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5
In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.
Related Articles In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.
J Med Chem. 2002 Dec 19;45(26):5655-60
Authors: Kamionka M, Rehm T, Beisel HG, Lang K, Engh RA, Holak TA
Recently we have determined the crystal structure of the insulin-like growth factor-I (IGF-I) in complex with the N-terminal domain of the IGF-binding protein-5 (IGFBP-5). Here we report results of computer screening for...
nmrlearner
Journal club
0
11-24-2010 08:58 PM
[NMR paper] Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
Related Articles Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.
J Med Chem. 1999 Sep 23;42(19):3852-9
Authors: Hajduk PJ, Dinges J, Schkeryantz JM, Janowick D, Kaminski M, Tufano M, Augeri DJ, Petros A, Nienaber V, Zhong P, Hammond R, Coen M, Beutel B, Katz L, Fesik SW
The Erm family of methyltransferases confers resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics through the methylation of 23S ribosomal RNA. Upon...
nmrlearner
Journal club
0
11-18-2010 08:31 PM
[NMR analysis blog] Fighting against peak overlap – Introducing Global Spectral Deconvolution (GSD)
Fighting against peak overlap – Introducing Global Spectral Deconvolution (GSD)
1H NMR is for sure the most powerful technique for structure elucidation, especially for small organic molecules. Typically, an organic chemist uses the chemical shift, coupling constants and integration information contained in an 1H-NMR spectrum to either verify or elucidate an unknown compound. Of course, it’s quite common that a simple 1H-NMR spectrum is not enough to unambiguously confirm a structure and thus other NMR experiments (e.g. 13C-NMR, HSQC, COSY, etc) are used to get more structural information....
Sclerostin inhibitors: NMR fighting osteoporosis
Drugs that are inhibitors of the protein sclerostin could be used to treat the debilitating bone-loss disease osteoporosis, according to researchers in Germany who used nuclear magnetic resonance (NMR) spectroscopy in thier investigations.
Linear Mode
