Novel natural products found in rose myrtle could hold promise of a new way to make breast cancer cells that have become resistant to the conventional anticancer drug doxorubicin susceptible once more. Nuclear magnetic resonance (NMR) spectroscopy, electronic circular dichroism (ECD) and X-ray crystallography were used to determine the structures and absolute configurations of the compounds.
Unravelling the secret of antibiotic resistance - Phys.Org
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Phys.Org
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Unravelling the secret of antibiotic resistance
Phys.Org
A recent £17 million investment in some of the best nuclear magnetic resonance and electron microscopy facilities in the world is now enabling scientists to remain at the forefront of research into complex proteins. The University of Leeds has played a ...
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Unravelling the secret of antibiotic resistance - Phys.Org
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03-25-2016 04:12 PM
Hyperpolarized NMR of plant and cancer cell extracts at natural abundance
From The DNP-NMR Blog:
Hyperpolarized NMR of plant and cancer cell extracts at natural abundance
Dumez, J.N., et al., Hyperpolarized NMR of plant and cancer cell extracts at natural abundance. Analyst, 2015. 140(17): p. 5860-3.
http://www.ncbi.nlm.nih.gov/pubmed/26215673
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12-03-2015 02:03 AM
[NMR paper] (1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
(1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Related Articles (1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
J Neural Transm. 2015 Mar 6;
Authors: Doert A, Pilatus U, Zanella F, Müller WE, Eckert GP
Abstract
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer's disease (AD) are not fully understood. However, alterations of glucose metabolism and...
[NMR paper] Fluorine NMR-Based Screening on Cell Membrane Extracts.
Fluorine NMR-Based Screening on Cell Membrane Extracts.
Related Articles Fluorine NMR-Based Screening on Cell Membrane Extracts.
ChemMedChem. 2013 Dec 11;
Authors: Veronesi M, Romeo E, Lambruschini C, Piomelli D, Bandiera T, Scarpelli R, Garau G, Dalvit C
Abstract
The possibility of measuring the action of inhibitors of specific enzymatic reactions in intact cells, cell lysates or membrane preparations represents a major advance in the lead discovery process. Despite the relevance of assaying in physiological conditions, only a small...
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12-18-2013 04:00 PM
Alzheimer's analysed: New clues in brain disease
Alzheimer's analysed: New clues in brain disease
http://www.spectroscopynow.com/common/images/thumbnails/13af4d7f690.jpgRecent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.
Source: Spectroscopynow.com
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02-03-2013 08:49 AM
[NMR paper] Rapid screening of E. coli extracts by heteronuclear NMR.
Rapid screening of E. coli extracts by heteronuclear NMR.
Related Articles Rapid screening of E. coli extracts by heteronuclear NMR.
Curr Protoc Protein Sci. 2003 May;Chapter 7:Unit 7.11
Authors: Gronenborn AM
Assessing whether a protein or protein complex is amenable to structural analysis is an important component in the structural genomics effort. In particular, if complete sets of structures for entire genomes are to be obtained within a reasonable time frame, high throughput methodologies for all steps along the way have to be developed....
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11-24-2010 09:01 PM
[NMR paper] 1H and 31P NMR and HPLC studies of mouse L1210 leukemia cell extracts: the effect of
1H and 31P NMR and HPLC studies of mouse L1210 leukemia cell extracts: the effect of Au(I) and Cu(I) diphosphine complexes on the cell metabolism.
Related Articles 1H and 31P NMR and HPLC studies of mouse L1210 leukemia cell extracts: the effect of Au(I) and Cu(I) diphosphine complexes on the cell metabolism.
Magn Reson Med. 1991 Mar;18(1):142-58
Authors: Berners-Price SJ, Sant ME, Christopherson RI, Kuchel PW
The effect of the antitumor complex Cl (where dppe is Ph2P(CH2)2PPh2) on the overall metabolism of cultured mouse L1210 leukemia cells...
Reversing resistance: Rose myrtle extracts analysed by NMR
Novel natural products found in rose myrtle could hold promise of a new way to make breast cancer cells that have become resistant to the conventional anticancer drug doxorubicin susceptible once more. Nuclear magnetic resonance (NMR) spectroscopy, electronic circular dichroism (ECD) and X-ray crystallography were used to determine the structures and absolute configurations of the compounds.
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