Nuclear magnetic resonance (NMR) spectroscopy has allowed US researchers to peer into the heart of a key protein used in drug design to reveal dynamic structural features that may lead to new ways for targeting disease.
[NMR paper] Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.
Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.
Related Articles Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.
Angew Chem Int Ed Engl. 2017 Apr 21;:
Authors: Fredriksson K, Lottmann P, Hinz S, Onila I, Shymanets A, Harteneck C, Müller CE, Griesinger C, Exner TE
Abstract
G-protein-coupled-receptors (GPCRs) are of fundamental importance for signal transduction through cell membranes. This makes them important...
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04-22-2017 10:30 PM
[NMR paper] Nuts and Bolts of CF3 and CH 3 NMR Toward the Understanding of Conformational Exchange of GPCRs.
Nuts and Bolts of CF3 and CH 3 NMR Toward the Understanding of Conformational Exchange of GPCRs.
Related Articles Nuts and Bolts of CF3 and CH 3 NMR Toward the Understanding of Conformational Exchange of GPCRs.
Methods Mol Biol. 2015;1335:39-51
Authors: Prosser RS, Kim TH
Abstract
With the advent of efficient protein expression and functional purification protocols, it is now possible to reconstitute many G protein-coupled receptors (GPCRs) in detergent micelles at concentrations of 25 ?M or more. Such concentrations are...
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08-12-2015 10:04 PM
[NMR paper] Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs.
Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs.
Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs.
Curr Opin Struct Biol. 2013 Aug 7;
Authors: Didenko T, Liu JJ, Horst R, Stevens RC, Wüthrich K
Abstract
Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of interest that (19)F is rarely found in biological...
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08-13-2013 04:26 PM
Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs
Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs
Publication date: Available online 7 August 2013
Source:Current Opinion in Structural Biology</br>
Author(s): Tatiana Didenko , Jeffrey J Liu , Reto Horst , Raymond C Stevens , Kurt Wüthrich</br>
Fluorine-19 is a spin-½ NMR isotope with high sensitivity and large chemical shift dispersion, which makes it attractive for high resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of interest that 19F is rarely found in biological materials, which...
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08-08-2013 03:41 AM
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
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Global G-Protein Coupled Receptors (GPCRs) Industry
Sacramento Bee
NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures II-4 ... G-PROTEIN COUPLED RECEPTORS (GPCR) - A CONCEPTUAL OVERVIEW II-7GPCR: Gateways to Cell II-7Classification of GPCRs II-7Table 1: List of Identified Known and Orphan (Non-Sensory)GPCRs ...
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08-15-2012 08:54 AM
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
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Global G-Protein Coupled Receptors (GPCRs) Industry
Sacramento Bee
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in ... NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures II-4 ...
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06-13-2012 11:34 AM
Solution- and solid-state NMR studies of GPCRs and their ligands (Review).
Solution- and solid-state NMR studies of GPCRs and their ligands (Review).
Related Articles Solution- and solid-state NMR studies of GPCRs and their ligands (Review).
Biochim Biophys Acta. 2010 Oct 14;
Authors: Tapaneeyakorn S, Goddard AD, Oates J, Willis CL, Watts A
G protein-coupled receptors (GPCRs) represent one of the major targets of new drugs on the market given their roles as key membrane receptors in many cellular signalling pathways. Structure-based drug design has potential to be the most reliable method for novel drug discovery....
Protein dynamics: NMR focuses on GPCRs
Nuclear magnetic resonance (NMR) spectroscopy has allowed US researchers to peer into the heart of a key protein used in drug design to reveal dynamic structural features that may lead to new ways for targeting disease.
Linear Mode
