Nuclear magnetic resonance (NMR) spectroscopy has been used to reveal molecular details of a key step in retroviral growth within the cell. The study shows how the matrix domain of the avian sarcoma virus, or ASV, Gag protein binds to certain phospholipids, which are critical to binding to the plasma membrane of a cell for viral replication.
[NMR paper] A Combined NMR-Computational Study of the Interaction between Influenza Virus Hemagglutinin and Sialic Derivatives from Human and Avian Receptors on the Surface of Transfected Cells.
A Combined NMR-Computational Study of the Interaction between Influenza Virus Hemagglutinin and Sialic Derivatives from Human and Avian Receptors on the Surface of Transfected Cells.
Related Articles A Combined NMR-Computational Study of the Interaction between Influenza Virus Hemagglutinin and Sialic Derivatives from Human and Avian Receptors on the Surface of Transfected Cells.
Int J Mol Sci. 2018 Apr 24;19(5):
Authors: Vasile F, Panigada M, Siccardi A, Potenza D, Tiana G
Abstract
The development of small-molecule inhibitors of...
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04-27-2018 10:26 PM
[NMR paper] Targeting a dark excited state of HIV-1 nucleocapsid by anti-retroviral thioesters revealed by NMR.
Targeting a dark excited state of HIV-1 nucleocapsid by anti-retroviral thioesters revealed by NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7315-19-Wiley_FullText_120x30_orange.png Related Articles Targeting a dark excited state of HIV-1 nucleocapsid by anti-retroviral thioesters revealed by NMR.
Angew Chem Int Ed Engl. 2018 Jan 18;:
Authors: Deshmukh L, Tugarinov V, Appella DH, Clore GM
Abstract
HIV-1 nucleocapsid (NCp7) is a two Cys2HisCys zinc knuckle (N-Zn and C-Zn)...
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[NMR paper] Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques.
Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques.
Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques.
Molecules. 2013;18(9):11467-84
Authors: Russo L, Raiola L, Campitiello MA, Magrì A, Fattorusso R, Malgieri G, Pappalardo G, La Mendola D, Isernia C
Abstract
Many proteins perform essential biological functions by means of regions that lacking specific organized structure exist as an ensemble of interconverting transient conformers. The characterization of such...
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Gamers Help Solve AIDS Protein Mystery - IEEE Spectrum
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Gamers Help Solve AIDS Protein Mystery
IEEE Spectrum
Even with advanced technologies, such as nuclear magnetic resonance spectroscopy, deciphering protein structures can be difficult. A few years ago, researchers at the University of Washington decided to enlist the help of citizen scientists by turning ...
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Gamers Help Solve AIDS Protein Mystery - IEEE Spectrum
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[NMR paper] NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src.
NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src.
Related Articles NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src.
J Biomol NMR. 2005 Aug;32(4):339
Authors: Taylor JD, Fawaz RR, Ababou A, Williams MA, Ladbury JE
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Structure of a Conserved Retroviral RNA Packaging Element by NMR Spectroscopy and Cry
Structure of a Conserved Retroviral RNA Packaging Element by NMR Spectroscopy and Cryo-Electron Tomography.
Related Articles Structure of a Conserved Retroviral RNA Packaging Element by NMR Spectroscopy and Cryo-Electron Tomography.
J Mol Biol. 2010 Oct 6;
Authors: Miyazaki Y, Irobalieva RN, Tolbert B, Smalls-Mantey A, Iyalla K, Loeliger K, D'Souza V, Khant H, Schmid MF, Garcia E, Telesnitsky A, Chiu W, Summers MF
The 5'-untranslated regions (5'-UTRs) of all gammaretroviruses contain a conserved "double hairpin motif" (?(CD)) that is required for...
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More than a third of our proteins are still a mystery for scientists - HealthCanal.co
More than a third of our proteins are still a mystery for scientists - HealthCanal.com
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More than a third of our proteins are still a mystery for scientists
HealthCanal.com
Several tools to study the structure of these proteins are already available, such as Nuclear Magnetic Resonance and Small-angle X-ray Scattering (SAXS); ...
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10-02-2010 12:16 AM
[NMR paper] Interaction of retroviral nucleocapsid proteins with transfer RNAPhe: a lead ribozyme
Interaction of retroviral nucleocapsid proteins with transfer RNAPhe: a lead ribozyme and 1H NMR study.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-custom-oxfordjournals_final_free.gif http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Interaction of retroviral nucleocapsid proteins with transfer RNAPhe: a lead ribozyme and 1H NMR study.
Nucleic Acids Res. 1996 Sep 15;24(18):3568-75
Authors: Khan R, Chang HO,...
NMR solves retroviral mystery: Avian Sarcoma Virus
Nuclear magnetic resonance (NMR) spectroscopy has been used to reveal molecular details of a key step in retroviral growth within the cell. The study shows how the matrix domain of the avian sarcoma virus, or ASV, Gag protein binds to certain phospholipids, which are critical to binding to the plasma membrane of a cell for viral replication.
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